Strain Name: kzt / Allele: aa6k |
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| Allele | aa6k |
| Strain Name | kzt |
| Type | Mutant |
| Genotype | |
| Affected Gene | |
| Origin and Depositor | Saitama University (Kyo Yamasu) |
| Link to ZFIN |
| Information | |
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This mutation was obtained by chemical mutagenesis (ENU; N-ethyl N-nitrosourea) screening and identified as a novel one, kanazutsi (kzt). Zygotic homozygous mutants are embryonic lethal. Homozygotes suffer from a variety of morphological defects, such as head flattening, pericardial edema, circulation defects, disrupted patterns of melanophore distribution, dwarf eyes, a defective jaw, and extensive apoptosis in the head, which indicates that the main affected tissues are derived from neural crest cells. The closely linked gene is cytoglobin 1, which is significantly downregulated in kzt homozygotes. |
| The Conditions to Distribute Strains | |
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In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. A globin-family protein, Cytoglobin 1, is involved in the development of neural crest-derived tissues and organs in zebrafish. Takahashi et al. Dev. Biol. 472():1-17 (2021) |
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| Reference | |
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| Facility | RIKEN Center for Brain Science |