Strain Name: ogon / Allele: rk1

Allele rk1
Strain Name ogon
Type Mutant
Genotype szlrk1/rk1
Affected Gene sizzled
Origin and Depositor RIKEN CDB (Masahiko Hibi) Present affiliation :Nagoya University
Link to ZFIN ZDB-GENO-030530-1    
Information
ogon is a ventralized mutant. There is a mutation in the splicing donor site of the first intron in the rk1 allele and it is likely a null allele. Sizzled functions to stablize Chordin by repressing degradation enzymes for Chordin.  
The Conditions to Distribute Strains
"In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested.
Yabe, et al., Ogon/Secreted Frizzled functions as a negative feedback regulator of Bmp signaling. Development 130(12):2705-2716
In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested."  
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Reference

Yabe T, Shimizu T, Muraoka O, Bae YK, Hirata T, Nojima H, Kawakami A, Hirano T, Hibi M. Ogon/Secreted Frizzled functions as a negative feedback regulator of Bmp signaling. Development. 2003 ; 130(12) : 2705-2716 .

 
Facility RIKEN Center for Brain Science