分離済み変異体

tm901

Allele Nametm901
BalanceNot Required
OutCrossNot Accepted
Sequence NameF52E1.4
Gene Namegcy-7
Worm BaseAllele Name tm901
Gene Name gcy-7
Sequence F52E1.4
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" homozygous viable. Dr. G. Jansen, Dr. O. Hobert: WT avoidance of 0.5 M NaCl and WT chemotaxis to NaCl. Dr. Y. Iino: fertile, normal locomotion, normal chemotaxis to KCl.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 8808/8809-CCTTTNAATTT-9339/9340 (531 bp deletion + 11 bp insertion)
ChromosomeV
Putative gene structurejoin(7958..8005, 8054..8244, 8355..8464, 8540..8787, 8831..8942, 8988..9113, 9157..9269, 9359..9478, 9579..9842, 9895..9996, 10043..10222, 10272..10484, 10532..10651, 10697..10753, 10801..10945, 11129..11367, 11411..11646, 11992..12184, 12229..12502, 12625..12812, 12870..12926)
Map position1.37
Balancer
Map position of balancer
Sequence of primersIntRev:CTAATCTTGGTCGGTACGCA,ExtFwd:CGTCATCATTGGGCCCACTA,ExtRev:CTGCGATAGAACCTCTCGAG,IntFwd:GGCCCACTATGAACCAGCGT
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Murayama T, Takayama J, Fujiwara M, Maruyama IN.
Environmental alkalinity sensing mediated by the transmembrane guanylyl cyclase GCY-14 in C. elegans.
Curr Biol 2013 23(11) 1007-12 
[ PubMed ID = 23664973 ] [ RRC reference ]

Mok CA, Healey MP, Shekhar T, Leroux MR, Héon E, Zhen M.
Mutations in a guanylate cyclase GCY-35/GCY-36 modify Bardet-Biedl syndrome-associated phenotypes in Caenorhabditis elegans.
PLoS Genet 2011 7(10) e1002335 
[ PubMed ID = 22022287 ] [ RRC reference ]

Hallem EA, Spencer WC, McWhirter RD, Zeller G, Henz SR, Rätsch G, Miller DM 3rd, Horvitz HR, Sternberg PW, Ringstad N.
Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans.
Proc Natl Acad Sci U S A 2011 108(1) 254-9 
[ PubMed ID = 21173231 ] [ RRC reference ]