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Zhao L, Fenk LA, Nilsson L, Amin-Wetzel NP, Ramirez-Suarez NJ, de Bono M, Chen C. ROS and cGMP signaling modulate persistent escape from hypoxia in Caenorhabditis elegans. PLoS Biol 2022 20(6) e3001684
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Branicky R, Wang Y, Khaki A, Liu JL, Kramer-Drauberg M, Hekimi S. Stimulation of RAS-dependent ROS signaling extends longevity by modulating a developmental program of global gene expression. Sci Adv 2022 8(48) eadc9851
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Gaidamakova EK, Sharma A, Matrosova VY, Grichenko O, Volpe RP, Tkavc R, Conze IH, Klimenkova P, Balygina I, Horne WH, Gostinčar C, Chen X, Makarova KS, Shuryak I, Srinivasan C, Jackson-Thompson B, Hoffman BM, Daly MJ. Small-Molecule Mn Antioxidants in Caenorhabditis elegans and Deinococcus radiodurans Supplant MnSOD Enzymes during Aging and Irradiation. mBio 2022 13(1) e0339421
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Fernando LM, Adeel S, Basar MA, Allen AK, Duttaroy A. In-gel SOD assay reveals SOD-2 is the single active, water-soluble SOD enzyme in C. elegans. Free Radic Res 2021 55(6) 619-624
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Kramer-Drauberg M, Liu JL, Desjardins D, Wang Y, Branicky R, Hekimi S. ROS regulation of RAS and vulva development in Caenorhabditis elegans. PLoS Genet 2020 16(6) e1008838
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Desjardins D, Cacho-Valadez B, Liu JL, Wang Y, Yee C, Bernard K, Khaki A, Breton L, Hekimi S. Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans. Aging Cell 2017 16(1) 104-112
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Yee C, Yang W, Hekimi S. The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans. Cell 2014 157(4) 897-909
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Van Raamsdonk JM, Hekimi S. Superoxide dismutase is dispensable for normal animal lifespan. Proc Natl Acad Sci U S A 2012 109(15) 5785-90
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Van Raamsdonk JM, Hekimi S. Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet 2009 5(2) e1000361
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Yanase S, Onodera A, Tedesco P, Johnson TE, Ishii N. SOD-1 deletions in Caenorhabditis elegans alter the localization of intracellular reactive oxygen species and show molecular compensation. J Gerontol A Biol Sci Med Sci 2009 64(5) 530-9
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