Mutants (Isolated)

tm742

Allele Nametm742
Allele TypeNormal
Sequence NameF49E8.4
Gene Namecdd-2
Worm BaseAllele Name tm742
Gene Name cdd-2
Sequence F49E8.4
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" homozygous viable. Dr. M. Han: Gro, slightly Ste.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 4019/4020-TT-5194/5195 (1175 bp deletion + 2 bp insertion)
ChromosomeIV
Putative gene structurecomplement(join(4408..4581, 4627..4808, 4905..5049))
Map position3.35
Balancer
Map position of balancer
Sequence of primersIntRev:CGTTCGTGGTCGACAAACTA,ExtRev:TCGTTCGCGAACGAACGTTC,IntFwd:CTGCGATAAAATCCTCGCAT,ExtFwd:TCGGTGCCGTTCTTATCCTT
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Jia F, Chi C, Han M.
Regulation of Nucleotide Metabolism and Germline Proliferation in Response to Nucleotide Imbalance and Genotoxic Stresses by EndoU Nuclease.
Cell Rep 2020 30(6) 1848-1861.e5 
[ PubMed ID = 32049015 ] [ RRC reference ]

Chi C, Ronai D, Than MT, Walker CJ, Sewell AK, Han M.
Nucleotide levels regulate germline proliferation through modulating GLP-1/Notch signaling in C. elegans.
Genes Dev 2016 30(3) 307-20 
[ PubMed ID = 26833730 ] [ RRC reference ]