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分離済み変異体

Allele Name		tm5487
Balance		Not Required
OutCross		Not Accepted
Sequence Name		T21C12.1
Gene Name		unc-49
Worm Base	Allele Name	tm5487
	Gene Name	unc-49
	Sequence	T21C12.1
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		7917/7918-8219/8220 (302 bp deletion)
Chromosome		III
Putative gene structure		join(293..366, 1372..1458, 2047..2122, 2241..2482, 3568..3686, 4199..4330, 4598..4797, 5218..5266, 6246..6345, 6432..6624, 6713..6791, 7262..7444, 7695..7950, 8002..8161, 8663..8698, 8757..8887, 9060..9478, 9911..10063, 10554..10657, 10704..10989, 11534..11664, 11768..11878)
Map position		3.35
Balancer
Map position of balancer
Sequence of primers		IntRev:TTCTAATGAAGACTCGGGTG,IntFwd:CGGCTACTGGGCCTACTTCA,ExtRev:CGCCTCGATTGAGAAAACTC,ExtFwd:TTCTACCGTACCGTCCGTCT
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Park YJ, Yeon J, Cho J, Kim DY, Bai X, Oh Y, Kim J, Nam H, Hwang H, Heo W, Kim J, Jun S, Lee K, Kang K, Kim K. PIEZO acts in an intestinal valve to regulate swallowing in C. elegans. Nat Commun 2024 15(1) 10072  [ PubMed ID = 39567502 ] [ RRC reference ] Gadhia A, Barker E, Morgan A, Barclay JW. Functional analysis of epilepsy-associated GABAA receptor mutations using Caenorhabditis elegans. Epilepsia Open 2024 9(4) 1458-1466  [ PubMed ID = 38813985 ] [ RRC reference ] Pohl F, Germann AL, Mao J, Hou S, Bakare B, Kong Thoo Lin P, Yates K, Nonet ML, Akk G, Kornfeld K, Held JM. UNC-49 is a redox-sensitive GABAA receptor that regulates the mitochondrial unfolded protein response cell nonautonomously. Sci Adv 2023 9(44) eadh2584  [ PubMed ID = 37910615 ] [ RRC reference ] Deng L, Denham JE, Arya C, Yuval O, Cohen N, Haspel G. Inhibition Underlies Fast Undulatory Locomotion in Caenorhabditis elegans. eNeuro 2021 8(2)   [ PubMed ID = 33361147 ] [ RRC reference ]