Home > 分離済み変異体 > tm516

分離済み変異体

Allele Name		tm516
Balance		Completed
OutCross		Not Accepted
Sequence Name		F12F6.3
Gene Name		rib-1
Worm Base	Allele Name	tm516 (x1)
	Gene Name	rib-1
	Sequence	F12F6.3
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		lethal or sterile
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		37528/37529-CTCTTGGATCTTTCAGGTAACTGTGTCTATGT-38014/38015(486 bp deletion + 32 bp insertion)
Chromosome		IV
Putative gene structure		join(34900..34979, 35354..35497, 35542..35619, 35670..35850, 35900..35980, 37305..37469, 37909..38030, 38858..38984, 39222..39341, 39479..39529)
Map position		5.01
Balancer		dpy-20 (e1415) IV
Map position of balancer
Sequence of primers		IntRev:GATGACAACAGGAACACATC,ExtRev:AAGAATCCATGAGTCGGAGA,ExtFwd:TTCCACTGGACCTCTCCCAT,IntFwd:CCCATCTTCTCGTACATCTT
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Blanchette CR, Thackeray A, Perrat PN, Hekimi S, Bénard CY. Functional Requirements for Heparan Sulfate Biosynthesis in Morphogenesis and Nervous System Development in C. elegans. PLoS Genet 2017 13(1) e1006525  [ PubMed ID = 28068429 ] [ RRC reference ] Dejima K, Kang S, Mitani S, Cosman PC, Chisholm AD. Syndecan defines precise spindle orientation by modulating Wnt signaling in C. elegans. Development 2014 141(22) 4354-65  [ PubMed ID = 25344071 ] [ RRC reference ] Kitagawa H, Izumikawa T, Mizuguchi S, Dejima K, Nomura KH, Egusa N, Taniguchi F, Tamura J, Gengyo-Ando K, Mitani S, Nomura K, Sugahara K. Expression of rib-1, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes, is indispensable for heparan sulfate synthesis and embryonic morphogenesis. J Biol Chem 2007 282(11) 8533-44  [ PubMed ID = 17237233 ] [ RRC reference ]