Home > 分離済み変異体 > tm4627

分離済み変異体

Allele Name		tm4627
Balance		Not Required
OutCross		Not Accepted
Sequence Name		K06A4.5
Gene Name		haao-1
Worm Base	Allele Name	tm4627
	Gene Name	haao-1
	Sequence	K06A4.5
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		33092/33093-GATTGAAAA-33397/33398 (305 bp deletion + 9 bp insertion)
Chromosome		V
Putative gene structure		join(33028..33271, 33535..33765, 33808..33922, 33974..34006, Z70751.1:105..186, Z70751.1:235..320, Z70751.1:366..420)
Map position		2.04
Balancer
Map position of balancer
Sequence of primers		IntRev:GGTACGGGTAAATCAGTCCA,ExtRev:GGTCCGTTTCTGAAAACTTC,IntFwd:ACGACTTCCGTTTCTACCGA,ExtFwd:ATCAGGAGCAAGTAGTCTGT
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Dang H, Castro-Portuguez R, Espejo L, Backer G, Freitas S, Spence E, Meyers J, Shuck K, Gardea EA, Chang LM, Balsa J, Thorns N, Corban C, Liu T, Bean S, Sheehan S, Korstanje R, Sutphin GL. On the benefits of the tryptophan metabolite 3-hydroxyanthranilic acid in Caenorhabditis elegans and mouse aging. Nat Commun 2023 14(1) 8338  [ PubMed ID = 38097593 ] [ RRC reference ] Roberts Buceta PM, Romanelli-Cedrez L, Babcock SJ, Xun H, VonPaige ML, Higley TW, Schlatter TD, Davis DC, Drexelius JA, Culver JC, Carrera I, Shepherd JN, Salinas G. The kynurenine pathway is essential for rhodoquinone biosynthesis in Caenorhabditis elegans. J Biol Chem 2019 294(28) 11047-11053  [ PubMed ID = 31177094 ] [ RRC reference ] van der Goot AT, Zhu W, Vázquez-Manrique RP, Seinstra RI, Dettmer K, Michels H, Farina F, Krijnen J, Melki R, Buijsman RC, Ruiz Silva M, Thijssen KL, Kema IP, Neri C, Oefner PJ, Nollen EA. Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation. Proc Natl Acad Sci U S A 2012 109(37) 14912-7  [ PubMed ID = 22927396 ] [ RRC reference ]