Home > 分離済み変異体 > tm4547

分離済み変異体

Allele Name		tm4547
Balance		Not Required
OutCross		Not Accepted
Sequence Name		D2024.2
Gene Name		D2024.2
Worm Base	Allele Name	tm4547
	Gene Name	D2024.2
	Sequence	D2024.2
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		17814/17815-18239/18240 (425 bp deletion)
Chromosome		IV
Putative gene structure		join(17794..17953, 17995..18071, 18134..18353, 18469..18571, 18621..18777, 18822..18920)
Map position		3.31
Balancer
Map position of balancer
Sequence of primers		IntRev:AATCCCACTCGACCTACCTC,ExtFwd:CGGTATCAATTCTCGTAGGT,IntFwd:AGAGAAGAGTGGCATGTCCA,ExtRev:TACTCCCCAGAAGTGTGATT
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Roberts Buceta PM, Romanelli-Cedrez L, Babcock SJ, Xun H, VonPaige ML, Higley TW, Schlatter TD, Davis DC, Drexelius JA, Culver JC, Carrera I, Shepherd JN, Salinas G. The kynurenine pathway is essential for rhodoquinone biosynthesis in Caenorhabditis elegans. J Biol Chem 2019 294(28) 11047-11053  [ PubMed ID = 31177094 ] [ RRC reference ] Del Borrello S, Lautens M, Dolan K, Tan JH, Davie T, Schertzberg MR, Spensley MA, Caudy AA, Fraser AG. Rhodoquinone biosynthesis in C. elegans requires precursors generated by the kynurenine pathway. Elife 2019 8   [ PubMed ID = 31232688 ] [ RRC reference ] van der Goot AT, Zhu W, Vázquez-Manrique RP, Seinstra RI, Dettmer K, Michels H, Farina F, Krijnen J, Melki R, Buijsman RC, Ruiz Silva M, Thijssen KL, Kema IP, Neri C, Oefner PJ, Nollen EA. Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation. Proc Natl Acad Sci U S A 2012 109(37) 14912-7  [ PubMed ID = 22927396 ] [ RRC reference ]