分離済み変異体

tm4475

Allele Nametm4475
BalanceCompleted
OutCrossNot Accepted
Sequence NameT24A11.1
Gene Namemtm-3
Worm BaseAllele Name tm4475 (x1)
Gene Name mtm-3
Sequence T24A11.1
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" Let or Ste.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 16434/16435-TTATTATAAGTT-16836/16837 (402 bp deletion + 12 bp insertion)
ChromosomeIII
Putative gene structurecomplement(join(10788..11013, 12234..12991, 13719..14401, 15262..15590, 16120..16580, 16637..16813, 19976..20038, 20093..20212))
Map position-4.25
BalancerqC1[nIs281]
Map position of balancer
Sequence of primersExtFwd:CGAATCCACCACTCCTTGCT,IntFwd:GCTCTGTTCGCAAATGCAGA,ExtRev:GCTCTCACAGGGCAAAGCAA,IntRev:GTCAGTAGGCACCAATTATC
Distributed lab
DepositorDr. S. Mitani
References Please submit your publication
Stavoe AK, Hill SE, Hall DH, Colón-Ramos DA.
KIF1A/UNC-104 Transports ATG-9 to Regulate Neurodevelopment and Autophagy at Synapses.
Dev Cell 2016 38(2) 171-85 
[ PubMed ID = 27396362 ] [ RRC reference ]

Liu K, Jian Y, Sun X, Yang C, Gao Z, Zhang Z, Liu X, Li Y, Xu J, Jing Y, Mitani S, He S, Yang C.
Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion.
J Cell Biol 2016 212(2) 181-98 
[ PubMed ID = 26783301 ] [ RRC reference ]

Wu Y, Cheng S, Zhao H, Zou W, Yoshina S, Mitani S, Zhang H, Wang X.
PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation.
EMBO Rep 2014 15(9) 973-81 
[ PubMed ID = 25124690 ] [ RRC reference ]