Mutants (Isolated)


Allele Nametm4067
Allele TypeNormal
Sequence NameK02F3.4
Gene Namezip-2
Worm BaseAllele Name tm4067
Gene Name zip-2
Sequence K02F3.4
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" homozygous viable. Dr. J. Kaplan: non-Egl, non-Dpy, non-Sma.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 12094/12095-A-12405/12406 (311 bp deletion + 1 bp insertion)
Putative gene structurejoin(11760..11768, 11821..12136, 12193..12513, 12628..12908)
Map position-25.78
Map position of balancer
Distributed lab
DepositorDr. S. Mitani
References Please submit your publication
Jeong DE, Lee D, Hwang SY, Lee Y, Lee JE, Seo M, Hwang W, Seo K, Hwang AB, Artan M, Son HG, Jo JH, Baek H, Oh YM, Ryu Y, Kim HJ, Ha CM, Yoo JY, Lee SV.
Mitochondrial chaperone HSP-60 regulates anti-bacterial immunity via p38 MAP kinase signaling.
EMBO J 2017 36(8) 1046-1065 
[ PubMed ID = 28283579 ] [ RRC reference ]

Estes KA, Dunbar TL, Powell JR, Ausubel FM, Troemel ER.
bZIP transcription factor zip-2 mediates an early response to Pseudomonas aeruginosa infection in Caenorhabditis elegans.
Proc Natl Acad Sci U S A 2010 107(5) 2153-8 
[ PubMed ID = 20133860 ] [ RRC reference ]

Pukkila-Worley R, Feinbaum R, Kirienko NV, Larkins-Ford J, Conery AL, Ausubel FM.
Stimulation of host immune defenses by a small molecule protects C. elegans from bacterial infection.
PLoS Genet 2012 8(6) e1002733 
[ PubMed ID = 22719261 ] [ RRC reference ]

McEwan DL, Kirienko NV, Ausubel FM.
Host translational inhibition by Pseudomonas aeruginosa Exotoxin A Triggers an immune response in Caenorhabditis elegans.
Cell Host Microbe 2012 11(4) 364-74 
[ PubMed ID = 22520464 ] [ RRC reference ]

Dunbar TL, Yan Z, Balla KM, Smelkinson MG, Troemel ER.
C. elegans detects pathogen-induced translational inhibition to activate immune signaling.
Cell Host Microbe 2012 11(4) 375-86 
[ PubMed ID = 22520465 ] [ RRC reference ]

Melo JA, Ruvkun G.
Inactivation of conserved C. elegans genes engages pathogen- and xenobiotic-associated defenses.
Cell 2012 149(2) 452-66 
[ PubMed ID = 22500807 ] [ RRC reference ]