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Mutants (Isolated)

Allele Name		tm3574
Balance		Completed
OutCross		Not Accepted
Sequence Name		C46F11.2
Gene Name		gsr-1
Worm Base	Allele Name	tm3574 (x1)
	Gene Name	gsr-1
	Sequence	C46F11.2
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		lethal or sterile.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		9752/9753-10135/10136 (383 bp deletion)
Chromosome		III
Putative gene structure		join(9164..9411, 9467..9824, 9875..10346, 10403..10704)
Map position		-5
Balancer		,qC1[nIs281]
Map position of balancer
Sequence of primers		ExtFwd:TCCGGGACCACGCTGATTAC,IntRev:TATACCTTCCGTGAGTCCGA,IntFwd:CGGATTTGATGTGACGCTTA,ExtRev:CCGTACTTTTCAACGGCCTC
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Valenzuela-Villatoro M, Gómez-Orte E, Guerrero-Gómez D, Cheng Q, Zheleva A, Mora-Lorca JA, Petrovic D, O Neil NJ, Cerón J, Hatakeyama A, Onami S, Ordóñez-Luque A, Ayuso C, Askjaer P, Filipovic MR, Arnér ESJ, Cabello J, Miranda-Vizuete A. The transsulfuration pathway suppresses the embryonic lethal phenotype of glutathione reductase mutants in Caenorhabditis elegans. G3 (Bethesda) 2025 15(8)   [ PubMed ID = 40333285 ] [ RRC reference ] Mora-Lorca JA, Sáenz-Narciso B, Gaffney CJ, Naranjo-Galindo FJ, Pedrajas JR, Guerrero-Gómez D, Dobrzynska A, Askjaer P, Szewczyk NJ, Cabello J, Miranda-Vizuete A. Glutathione reductase gsr-1 is an essential gene required for Caenorhabditis elegans early embryonic development. Free Radic Biol Med 2016 96 446-61  [ PubMed ID = 27117030 ] [ RRC reference ] Lüersen K, Stegehake D, Daniel J, Drescher M, Ajonina I, Ajonina C, Hertel P, Woltersdorf C, Liebau E. The glutathione reductase GSR-1 determines stress tolerance and longevity in Caenorhabditis elegans. PLoS One 2013 8(4) e60731  [ PubMed ID = 23593298 ] [ RRC reference ]