Mutants (Isolated)


Allele Nametm339
Sequence NameT28B8.2
CGC Nameins-18
Worm BaseAllele Name tm339
CGC Name ins-18
Sequence T28B8.2
Phenotypehomozygous viable. Dr. C. Kenyon: normal life span. Dr. P. Roy: normal muscle arm development. Dr. P.W. Sternberg: normal locomotion. Dr. J. Alcedo: non-Daf-c at 25C.
Mutation site17514/17515-AATCGGG-18930/18931 (1416 bp deletion)
Putative gene structurejoin(16540..16618, 17961..18057,18517..18620)
Map position2.6
Map position of balancer
Distributed lab
DepositorDr. S. Mitani
References Please submit your publication
Matsunaga Y, Matsukawa T, Iwasaki T, Nagata K, Kawano T.
Comparison of physiological functions of antagonistic insulin-like peptides, INS-23 and INS-18, in Caenorhabditis elegans.
Biosci Biotechnol Biochem 2018 82(1) 90-96 
[ PubMed ID = 29303423 ] [ RRC reference ]

Narasimhan SD, Yen K, Bansal A, Kwon ES, Padmanabhan S, Tissenbaum HA.
PDP-1 links the TGF-β and IIS pathways to regulate longevity, development, and metabolism.
PLoS Genet 2011 7(4) e1001377 
[ PubMed ID = 21533078 ] [ RRC reference ]

Matsunaga Y, Nakajima K, Gengyo-Ando K, Mitani S, Iwasaki T, Kawano T.
A Caenorhabditis elegans insulin-like peptide, INS-17: its physiological function and expression pattern.
Biosci Biotechnol Biochem 2012 76(11) 2168-72 
[ PubMed ID = 23132577 ] [ RRC reference ]

Matsunaga Y, Gengyo-Ando K, Mitani S, Iwasaki T, Kawano T.
Physiological function, expression pattern, and transcriptional regulation of a Caenorhabditis elegans insulin-like peptide, INS-18.
Biochem Biophys Res Commun 2012 423(3) 478-83 
[ PubMed ID = 22683638 ] [ RRC reference ]

Lee SJ, Murphy CT, Kenyon C.
Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression.
Cell Metab 2009 10(5) 379-91 
[ PubMed ID = 19883616 ] [ RRC reference ]

Ouellet J, Li S, Roy R.
Notch signalling is required for both dauer maintenance and recovery in C. elegans.
Development 2008 135(15) 2583-92 
[ PubMed ID = 18599512 ] [ RRC reference ]

Hung WL, Hwang C, Gao S, Liao EH, Chitturi J, Wang Y, Li H, Stigloher C, Bessereau JL, Zhen M.
Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development.
EMBO J 2013 32(12) 1745-60 
[ PubMed ID = 23665919 ] [ RRC reference ]