分離済み変異体

tm3349

Allele Nametm3349
BalanceNot Required
OutCrossNot Accepted
Sequence NameY4C6B.6
Gene NameY4C6B.6
Worm BaseAllele Name tm3349
Gene Name Y4C6B.6
Sequence Y4C6B.6
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" homozygous viable.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 28433/28434-28781/28782 (348 bp deletion)
ChromosomeIV
Putative gene structurecomplement(join(25912..26013, 26113..26345, 26481..26757, 27695..27935, 27985..28291, 28337..28486, 28784..28966, 32051..32117))
Map position1.59
Balancer
Map position of balancer
Sequence of primersIntRev:GTCCCTTCCTTGCTCCGAAG,ExtRev:CCAGAGTCCCTTCCTTGCTC,IntFwd:ACCTTGAGCGTGATAGGCTT,ExtFwd:TACTACATTTGGCCAGTGTG
Distributed lab
DepositorDr. S. Mitani
References Please submit your publication
Liu N, Li R, Huang X, Lakso M, Wong G.
The C. elegans gba-3 gene encodes a glucocerebrosidase that exacerbates α-synuclein-mediated impairments in deletion mutants.
Transl Neurodegener 2025 14(1) 9 
[ PubMed ID = 39940047 ] [ RRC reference ]

Hao L, Ben-David O, Babb SM, Futerman AH, Cohen BM, Buttner EA.
Clozapine Modulates Glucosylceramide, Clears Aggregated Proteins, and Enhances ATG8/LC3 in Caenorhabditis elegans.
Neuropsychopharmacology 2017 42(4) 951-962 
[ PubMed ID = 27711049 ] [ RRC reference ]