Mutants (Isolated)

tm3298

Allele Nametm3298
Sequence NameY71H2AM.7
CGC Namecosa-1
Worm BaseAllele Name tm3298
CGC Name cosa-1
Sequence Y71H2AM.7
Phenotypelethal or sterile.
Mutation site35092/35093-35427/35428 (335 bp deletion)
ChromosomeIII
Putative gene structurejoin(34915..35260, 35435..35567, 36344..36515, 37225..37334, 38048..38254, 39905..40097, 40170..40205)
Map position-11.4
BalancerNot Yet Balanced
Map position of balancer
Sequence of primersIntRev:CACAATGCTGCGTAAATCGA,ExtRev:GGGAGTACACAATGCTGCGT,IntFwd:GCACCGAACCAGGTGTAGTA,ExtFwd:GTATTGGTCTCGCACCGAAC
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Yokoo R, Zawadzki KA, Nabeshima K, Drake M, Arur S, Villeneuve AM.
COSA-1 reveals robust homeostasis and separable licensing and reinforcement steps governing meiotic crossovers.
Cell 2012 149(1) 75-87 
[ PubMed ID = 22464324 ] [ RRC reference ]

Rosu S, Zawadzki KA, Stamper EL, Libuda DE, Reese AL, Dernburg AF, Villeneuve AM.
The C. elegans DSB-2 protein reveals a regulatory network that controls competence for meiotic DSB formation and promotes crossover assurance.
PLoS Genet. 2013 9(8) e1003674 
[ PubMed ID = 23950729 ] [ RRC reference ]

Schvarzstein M, Pattabiraman D, Libuda DE, Ramadugu A, Tam A, Martinez-Perez E, Roelens B, Zawadzki KA, Yokoo R, Rosu S, Severson AF, Meyer BJ, Nabeshima K, Villeneuve AM.
DNA helicase HIM-6/BLM both promotes MutSĪ³-dependent crossovers and antagonizes MutSĪ³-independent interhomolog associations during caenorhabditis elegans meiosis.
Genetics 2014 198(1) 193-207 
[ PubMed ID = 25053665 ] [ RRC reference ]

Silva N, Adamo A, Santonicola P, Martinez-Perez E, La Volpe A.
Pro-crossover factors regulate damage-dependent apoptosis in the Caenorhabditis elegans germ line.
Cell Death Differ. 2013 20(9) 1209-18 
[ PubMed ID = 23832114 ] [ RRC reference ]