分離済み変異体

tm3171

Allele Nametm3171
BalanceNot Required
OutCrossNot Accepted
Sequence NameF39B1.1
Gene NameF39B1.1
Worm BaseAllele Name tm3171
Gene Name F39B1.1
Sequence F39B1.1
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" homozygous viable
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 10417/10418-TTTATTTTTATAAC-11090/11091 (673 bp deletion + 18 bp insertion)
ChromosomeX
Putative gene structurecomplement(join(6892..7089, 7166..7311, 7366..7516, 9378..9513, 9564..9664, 9715..9790, 9998..10242, 10294..10450, 10501..10937, 11183..11768, 11854..12300, 12347..12507, 12558..13006, 13432..13550, 13603..13766, Z69903.1:269..398, Z69903.1:1618..1846, Z69903.1:1891..1999, Z69903.1:2880..3094, Z69903.1:3301..3468, Z69903.1:3599..3804, Z69903.1:4079..4228, Z69903.1:4329..4372))
Map position22.3
Balancer
Map position of balancer
Sequence of primersExtFwd:GCCAGGAATGTCAGAGCAAG,IntFwd:TGTCAGAGCAAGCCATCTAA,ExtRev:ATCAGGATACATCGACGCTA,IntRev:CGACGCTAGAGACGGATGAT
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Liu K, Jian Y, Sun X, Yang C, Gao Z, Zhang Z, Liu X, Li Y, Xu J, Jing Y, Mitani S, He S, Yang C.
Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion.
J Cell Biol 2016 212(2) 181-98 
[ PubMed ID = 26783301 ] [ RRC reference ]

Lu N, Shen Q, Mahoney TR, Neukomm LJ, Wang Y, Zhou Z.
Two PI 3-kinases and one PI 3-phosphatase together establish the cyclic waves of phagosomal PtdIns(3)P critical for the degradation of apoptotic cells.
PLoS Biol 2012 10(1) e1001245 
[ PubMed ID = 22272187 ] [ RRC reference ]

Lu N, Shen Q, Mahoney TR, Liu X, Zhou Z.
Three sorting nexins drive the degradation of apoptotic cells in response to PtdIns(3)P signaling.
Mol Biol Cell 2011 22(3) 354-74 
[ PubMed ID = 21148288 ] [ RRC reference ]