分離済み変異体

tm3042

Allele Nametm3042
Allele Type通常株
Sequence NameW03H9.4
Gene Namecacn-1
Worm BaseAllele Name tm3042
Gene Name cacn-1
Sequence W03H9.4
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" lethal or sterile. Dr. E. Cram: L1-L2 arrest, Mlt.
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 53/54-235/236 (182 bp deletion)
ChromosomeII
Putative gene structurecomplement(join(29517..30017, 31189..31570, 32474..32931, 36350..36549, 37488..[W03H9]112, 200..547, 600..644))
Map position22.45
Balancer
Map position of balancer
Sequence of primersIntRev:CGGCTTGCCGAGCAAAGATC,ExtRev:AGAGATCGCCTTCAACGTCC,IntFwd:CGCCGTATGTGGATTCTCGT,ExtFwd:TCGGGAATTTTCGCCGTATG
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Cecchetelli AD, Hugunin J, Tannoury H, Cram EJ.
CACN-1 is required in the Caenorhabditis elegans somatic gonad for proper oocyte development.
Dev Biol 2016 414(1) 58-71 
[ PubMed ID = 27046631 ] [ RRC reference ]

Tannoury H, Rodriguez V, Kovacevic I, Ibourk M, Lee M, Cram EJ.
CACN-1/Cactin interacts genetically with MIG-2 GTPase signaling to control distal tip cell migration in C. elegans.
Dev Biol 2010 341(1) 176-85 
[ PubMed ID = 20188721 ] [ RRC reference ]

Matus DQ, Li XY, Durbin S, Agarwal D, Chi Q, Weiss SJ, Sherwood DR.
In vivo identification of regulators of cell invasion across basement membranes.
Sci Signal 2010 3(120) ra35 
[ PubMed ID = 20442418 ] [ RRC reference ]

LaBonty M, Szmygiel C, Byrnes LE, Hughes S, Woollard A, Cram EJ.
CACN-1/Cactin plays a role in Wnt signaling in C. elegans.
PLoS One 2014 9(7) e101945 
[ PubMed ID = 24999833 ] [ RRC reference ]