Mutants (Isolated)

tm2411

Allele Nametm2411
Sequence NameT01A4.1b
CGC Namegcy-28
Worm BaseAllele Name tm2411
CGC Name gcy-28
Sequence T01A4.1b
Phenotypehomozygous viable. Dr. C. Bargmann: chemotaxis-defective to AWC odors, sensitive to osmotic stress. Dr. L. Avery: intact satiety behavior. Dr. T. Ishihara: defective in sensory integration and salt chemotaxis learning. Dr. I. Mori: weakly thermophilic.
Mutation site40946/40947-41648/41649 (702 bp deletion)
ChromosomeI
Putative gene structurejoin(38759..39049, 39420..39619, 40575..40719, 40788..40959, 41212..41367, 41872..42188, 42818..43055, 43302..43460, 43634..43869)
Map position-1.17
Balancer
Map position of balancer
Sequence of primersExtFwd:CCCAGTCCTGATTACGACTC,ExtRev:TCTTGCGTGCGTTCCTCAAC,IntFwd:TCACCGGAGCATGTATCGAT,IntRev:GCGTTCCTCAACAAGACCTT
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Tsunozaki M, Chalasani SH, Bargmann CI.
A behavioral switch: cGMP and PKC signaling in olfactory neurons reverses odor preference in C. elegans.
Neuron 2008 59(6) 959-71 
[ PubMed ID = 18817734 ] [ RRC reference ]

Uozumi T, Hirotsu T, Yoshida K, Yamada R, Suzuki A, Taniguchi G, Iino Y, Ishihara T.
Temporally-regulated quick activation and inactivation of Ras is important for olfactory behaviour.
Sci Rep 2012 2 500 
[ PubMed ID = 22787558 ] [ RRC reference ]

Arey RN, Stein GM, Kaletsky R, Kauffman A, Murphy CT.
Activation of Gαq Signaling Enhances Memory Consolidation and Slows Cognitive Decline.
Neuron 2018 98(3) 562-574.e5 
[ PubMed ID = 29656871 ] [ RRC reference ]

Nishio N, Mohri-Shiomi A, Nishida Y, Hiramatsu N, Kodama-Namba E, Kimura KD, Kuhara A, Mori I.
A novel and conserved protein AHO-3 is required for thermotactic plasticity associated with feeding states in Caenorhabditis elegans.
Genes Cells 2012 17(5) 365-86 
[ PubMed ID = 22512337 ] [ RRC reference ]

Shinkai Y, Yamamoto Y, Fujiwara M, Tabata T, Murayama T, Hirotsu T, Ikeda DD, Tsunozaki M, Iino Y, Bargmann CI, Katsura I, Ishihara T.
Behavioral choice between conflicting alternatives is regulated by a receptor guanylyl cyclase, GCY-28, and a receptor tyrosine kinase, SCD-2, in AIA interneurons of Caenorhabditis elegans.
J. Neurosci. 2011 31(8) 3007-15 
[ PubMed ID = 21414922 ] [ RRC reference ]

Mok CA, Healey MP, Shekhar T, Leroux MR, Héon E, Zhen M.
Mutations in a guanylate cyclase GCY-35/GCY-36 modify Bardet-Biedl syndrome-associated phenotypes in Caenorhabditis elegans.
PLoS Genet. 2011 7(10) e1002335 
[ PubMed ID = 22022287 ] [ RRC reference ]

Hallem EA, Spencer WC, McWhirter RD, Zeller G, Henz SR, Rätsch G, Miller DM 3rd, Horvitz HR, Sternberg PW, Ringstad N.
Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans.
Proc. Natl. Acad. Sci. U.S.A. 2011 108(1) 254-9 
[ PubMed ID = 21173231 ] [ RRC reference ]