分離済み変異体

tm2124

Allele Name

tm2124

Allele Type

通常株

Sequence Name

F59B2.7

Gene Name

rab-6.1

Worm Base

Allele Name

tm2124

Gene Name

rab-6.1

Sequence

F59B2.7

Phenotype

homozygous viable. Dr. S. Eimer: leaky maternal-effect lethal. Dr. C. Rongo: unable to examine GLR-1 trafficking.

Mutation site

12362/12363-TTA-13266/13267 (904 bp deletion + 3 bp insertion)

Chromosome

III

Putative gene structure

complement(join(12000..12067, 12115..12175, 12240..12333, 12381..12492, 12543..12648, 12696..12808, 12857..12920))

Map position

0.08

Balancer

hT2

Map position of balancer

Sequence of primers

ExtFwd:CCCCCGAGTGATCTGATCAC,IntFwd:GGTACACTTGAGCACGATAC,ExtRev:TTAATCGTGCTGCAACGCCA,IntRev:GTCTCCGAACGAAGCTCATC

Distributed lab

Depositor

Dr. S. Mitani/NBRP

References

Please submit your publication

Zhang D, Dubey J, Koushika SP, Rongo C.
RAB-6.1 and RAB-6.2 Promote Retrograde Transport in C. elegans.
PLoS One 2016 11(2) e0149314
[ PubMed ID = 26891225 ] [ RRC reference ]

Imae R, Dejima K, Kage-Nakadai E, Arai H, Mitani S.
Endomembrane-associated RSD-3 is important for RNAi induced by extracellular silencing RNA in both somatic and germ cells of Caenorhabditis elegans.
Sci Rep 2016 6 28198
[ PubMed ID = 27306325 ] [ RRC reference ]

Martínez-Velázquez LA, Ringstad N.
Antagonistic regulation of trafficking to Caenorhabditis elegans sensory cilia by a Retinal Degeneration 3 homolog and retromer.
Proc Natl Acad Sci U S A 2018 115(3) E438-E447
[ PubMed ID = 29282322 ] [ RRC reference ]

Kimura K, Kimura A.
Rab6 is required for the exocytosis of cortical granules and the recruitment of separase to the granules during the oocyte-to-embryo transition in Caenorhabditis elegans.
J Cell Sci 2012 125(Pt 23) 5897-905
[ PubMed ID = 22992455 ] [ RRC reference ]

Chen L, Wang Z, Ghosh-Roy A, Hubert T, Yan D, O'Rourke S, Bowerman B, Wu Z, Jin Y, Chisholm AD.
Axon regeneration pathways identified by systematic genetic screening in C. elegans.
Neuron 2011 71(6) 1043-57
[ PubMed ID = 21943602 ] [ RRC reference ]