Home > 分離済み変異体 > tm2100

分離済み変異体

Allele Name		tm2100
Allele Type		通常株
Sequence Name		F26E4.12
Gene Name		gpx-1
Worm Base	Allele Name	tm2100
	Gene Name	gpx-1
	Sequence	F26E4.12
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable. Dr. M. Han: no observed plate phenotype.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		25927/25928-26311/26312 (384 bp deletion)
Chromosome		I
Putative gene structure		join(25489..25556, 25613..25699, 26144..26480)
Map position		3.9
Balancer
Map position of balancer
Sequence of primers		ExtRev:GGTGTCTTGCAATGCGTGAT,IntFwd:CCGCGTAATAAAAGCGCATG,ExtFwd:CACCGTTGACCGAGGTTATA,IntRev:ATGCGTGATCCAAGTAGTTC
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Ko SH, Cho KA, Li X, Ran Q, Liu Z, Chen L. GPX modulation promotes regenerative axonal fusion and functional recovery after injury through PSR-1 condensation. Nat Commun 2025 16(1) 1079  [ PubMed ID = 39870634 ] [ RRC reference ] Papsdorf K, Miklas JW, Hosseini A, Cabruja M, Morrow CS, Savini M, Yu Y, Silva-García CG, Haseley NR, Murphy LM, Yao P, de Launoit E, Dixon SJ, Snyder MP, Wang MC, Mair WB, Brunet A. Lipid droplets and peroxisomes are co-regulated to drive lifespan extension in response to mono-unsaturated fatty acids. Nat Cell Biol 2023 25(5) 672-684  [ PubMed ID = 37127715 ] [ RRC reference ] Tsai Y, Lin YC, Lee YH. Octopamine-MAPK-SKN-1 signaling suppresses mating-induced oxidative stress in Caenorhabditis elegans gonads to protect fertility. iScience 2023 26(3) 106162  [ PubMed ID = 36876134 ] [ RRC reference ] Schiavi A, Salveridou E, Brinkmann V, Shaik A, Menzel R, Kalyanasundaram S, Nygård S, Nilsen H, Ventura N. Mitochondria hormesis delays aging and associated diseases in Caenorhabditis elegans impacting on key ferroptosis players. iScience 2023 26(4) 106448  [ PubMed ID = 37020951 ] [ RRC reference ] Sakamoto T, Maebayashi K, Tsunoda Y, Imai H. Inhibition of lipid peroxidation during the reproductive period extends the lifespan of Caenorhabditis elegans. J Clin Biochem Nutr 2020 66(2) 116-123  [ PubMed ID = 32231407 ] [ RRC reference ] Perez MA, Magtanong L, Dixon SJ, Watts JL. Dietary Lipids Induce Ferroptosis in Caenorhabditiselegans and Human Cancer Cells. Dev Cell 2020 54(4) 447-454.e4  [ PubMed ID = 32652074 ] [ RRC reference ] Song S, Zhang X, Wu H, Han Y, Zhang J, Ma E, Guo Y. Molecular basis for antioxidant enzymes in mediating copper detoxification in the nematode Caenorhabditis elegans. PLoS One 2014 9(9) e107685  [ PubMed ID = 25243607 ] [ RRC reference ] Sakamoto T, Maebayashi K, Nakagawa Y, Imai H. Deletion of the four phospholipid hydroperoxide glutathione peroxidase genes accelerates aging in Caenorhabditis elegans. Genes Cells 2014 19(10) 778-92  [ PubMed ID = 25200408 ] [ RRC reference ]