Mutants (Isolated)


Allele Nametm1954
Sequence NameF54F3.3
CGC Namelipl-1
Worm BaseAllele Name tm1954
CGC Name lipl-1
Sequence F54F3.3
Phenotypehomozygous viable
Mutation site12187/12188-CCCCTCCC-13220/13221 (1033 bp deletion + 8 bp insertion)
Putative gene structurejoin(12340..12432, 12542..12641, 12803..13431, 13479..13754, 13808..13927)
Map position4.73
Map position of balancer
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Palikaras K, Mari M, Petanidou B, Pasparaki A, Filippidis G, Tavernarakis N.
Ectopic fat deposition contributes to age-associated pathology in Caenorhabditis elegans.
J Lipid Res 2017 58(1) 72-80 
[ PubMed ID = 27884963 ] [ RRC reference ]

Murphy JT, Liu H, Ma X, Shaver A, Egan BM, Oh C, Boyko A, Mazer T, Ang S, Khopkar R, Javaheri A, Kumar S, Jiang X, Ory D, Mani K, Matkovich SJ, Kornfeld K, Diwan A.
Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival.
PLoS Biol 2019 17(5) e3000245 
[ PubMed ID = 31086360 ] [ RRC reference ]

O'Rourke EJ, Ruvkun G.
MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability.
Nat Cell Biol 2013 15(6) 668-76 
[ PubMed ID = 23604316 ] [ RRC reference ]

Kim KW, Tang NH, Piggott CA, Andrusiak MG, Park S, Zhu M, Kurup N, Cherra SJ 3rd, Wu Z, Chisholm AD, Jin Y.
Expanded genetic screening in Caenorhabditis elegans identifies new regulators and an inhibitory role for NAD+ in axon regeneration.
Elife 2018 7  
[ PubMed ID = 30461420 ] [ RRC reference ]

O'Rourke D, Baban D, Demidova M, Mott R, Hodgkin J.
Genomic clusters, putative pathogen recognition molecules, and antimicrobial genes are induced by infection of C. elegans with M. nematophilum.
Genome Res 2006 16(8) 1005-16 
[ PubMed ID = 16809667 ] [ RRC reference ]