Mutants (Isolated)


Allele Nametm1905
Sequence NameY17G7B.2
CGC Nameash-2
Worm BaseAllele Name tm1905
CGC Name ash-2
Sequence Y17G7B.2
Phenotypelethal or sterile. Dr. H.C. Korswagen: lin-22-like multiple postdeirid phenotypes. Dr. O. Hobert: does not affect ASE development.
Mutation site11628/11629-12229/12230 (601 bp deletion)
Putative gene structurejoin(11683..11753, 11836..11928, 11980..12304, 13242..13462, 14218..14331, 15865..16127, 17187..17299, 18228..18428, 18624..18714, 19438..19658)
Map position5.54
BalancerNot Yet Balanced
Map position of balancer
Distributed lab
DepositorDr. S. Mitani
References Please submit your publication
Zuryn S, Ahier A, Portoso M, White ER, Morin MC, Margueron R, Jarriault S.
Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation.
Science 2014 345(6198) 826-9 
[ PubMed ID = 25124442 ] [ RRC reference ]

Xiao Y, Bedet C, Robert VJ, Simonet T, Dunkelbarger S, Rakotomalala C, Soete G, Korswagen HC, Strome S, Palladino F.
Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells.
Proc. Natl. Acad. Sci. U.S.A. 2011 108(20) 8305-10 
[ PubMed ID = 21527717 ] [ RRC reference ]

Robert VJ, Mercier MG, Bedet C, Janczarski S, Merlet J, Garvis S, Ciosk R, Palladino F.
The SET-2/SET1 histone H3K4 methyltransferase maintains pluripotency in the Caenorhabditis elegans germline.
Cell Rep 2014 9(2) 443-50 
[ PubMed ID = 25310986 ] [ RRC reference ]

Wang S, Fisher K, Poulin GB.
Lineage specific trimethylation of H3 on lysine 4 during C. elegans early embryogenesis.
Dev. Biol. 2011 355(2) 227-38 
[ PubMed ID = 21549110 ] [ RRC reference ]

Poole RJ, Bashllari E, Cochella L, Flowers EB, Hobert O.
A Genome-Wide RNAi Screen for Factors Involved in Neuronal Specification in Caenorhabditis elegans.
PLoS Genet. 2011 7(6) e1002109 
[ PubMed ID = 21698137 ] [ RRC reference ]