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分離済み変異体

Allele Name		tm1815
Allele Type		通常株
Sequence Name		F01E11.5
Gene Name		tyra-2
Worm Base	Allele Name	tm1815
	Gene Name	tyra-2
	Sequence	F01E11.5
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable. Dr. H. Horvitz: normal serotonin resistance.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		37497/37498-37851/37852 (354 bp deletion)
Chromosome		X
Putative gene structure		complement(join(32555..32635,32688..32799,32847..32978, 33033..33223, 33270..33370, 34314..34413, 36372..36566, 36613..36800, 37061..37181, 37230..37475))
Map position		-1.93
Balancer
Map position of balancer
Sequence of primers		IntFwd:TACATGAGACGAGACGGCCA,ExtFwd:GTGCTCTATAGCTATGGGGA,IntRev:GCAGTCCCGGATTTTATTTG,ExtRev:GTCGACAACATGGGAGTTGA
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Liu H, Wu JJ, Li R, Wang PZ, Huang JH, Xu Y, Zhao JL, Wu PP, Li SJ, Wu ZX. Disexcitation in the ASH/RIM/ADL negative feedback circuit fine-tunes hyperosmotic sensation and avoidance in Caenorhabditis elegans. Front Mol Neurosci 2023 16 1101628  [ PubMed ID = 37008778 ] [ RRC reference ] De Rosa MJ, Veuthey T, Florman J, Grant J, Blanco MG, Andersen N, Donnelly J, Rayes D, Alkema MJ. The flight response impairs cytoprotective mechanisms by activating the insulin pathway. Nature 2019 573(7772) 135-138  [ PubMed ID = 31462774 ] [ RRC reference ] Li Z, Li Y, Yi Y, Huang W, Yang S, Niu W, Zhang L, Xu Z, Qu A, Wu Z, Xu T. Dissecting a central flip-flop circuit that integrates contradictory sensory cues in C. elegans feeding regulation. Nat Commun 2012 3 776  [ PubMed ID = 22491324 ] [ RRC reference ] Karmacharya R, Lynn SK, Demarco S, Ortiz A, Wang X, Lundy MY, Xie Z, Cohen BM, Miller GM, Buttner EA. Behavioral effects of clozapine: involvement of trace amine pathways in C. elegans and M. musculus. Brain Res 2011 1393 91-9  [ PubMed ID = 21529784 ] [ RRC reference ] Donnelly JL, Clark CM, Leifer AM, Pirri JK, Haburcak M, Francis MM, Samuel AD, Alkema MJ. Monoaminergic orchestration of motor programs in a complex C. elegans behavior. PLoS Biol 2013 11(4) e1001529  [ PubMed ID = 23565061 ] [ RRC reference ] Guo M, Wu TH, Song YX, Ge MH, Su CM, Niu WP, Li LL, Xu ZJ, Ge CL, Al-Mhanawi MT, Wu SP, Wu ZX. Reciprocal inhibition between sensory ASH and ASI neurons modulates nociception and avoidance in Caenorhabditis elegans. Nat Commun 2015 6 5655  [ PubMed ID = 25585042 ] [ RRC reference ] Chase DL, Koelle MR. Biogenic amine neurotransmitters in C. elegans. WormBook 2007  1-15  [ PubMed ID = 18050501 ] [ RRC reference ]