Home > 分離済み変異体 > tm1400

分離済み変異体

Allele Name		tm1400
Allele Type		通常株
Sequence Name		F57C2.3
Gene Name		WBGene00010195
Worm Base	Allele Name	tm1400
	Gene Name	WBGene00010195
	Sequence	F57C2.3
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable. Dr. J. Lee: increased telomere length.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		5930/5931-6258/6259 (328 bp deletion)
Chromosome		II
Putative gene structure		join(5796..6140, 6186..6433, 6485..6647)
Map position		23.06
Balancer
Map position of balancer
Sequence of primers		IntFwd:GCGCGTCGTATGTAACGCAT,ExtFwd:CTTGTTTGCGCGTCGTATGT,IntRev:TTGATATGATGCTCCGCCAC,ExtRev:TCTGGCTGTTGGAACTCGGT
Distributed lab		Dr. Junho Lee(2008/10),Dr. Shawn Ahmed(2004/9),Dr. J. Karlseder(2006/1),Dr. Bhagwati Gupta(2008/9),Dr. F. Buchholz(2009/10),Dr. Jinqiu Zhou(2012/11),Dr. Erik Andersen(2015/5),Dr. Emilio Cusanelli(2015/10),Dr. YuChung Tse(2017/11),Dr. Lindsey Lohwater(19/2),Dr. Falk Butter(2020/3),Bjoern Schumacher(2021/2),Dr. Sarit Smolikove(2023/12)
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Yu X, Gray S, Ferreira HC. POT-3 preferentially binds the terminal DNA-repeat on the telomeric G-overhang. Nucleic Acids Res 2023 51(2) 610-618  [ PubMed ID = 36583365 ] [ RRC reference ] Dietz S, Almeida MV, Nischwitz E, Schreier J, Viceconte N, Fradera-Sola A, Renz C, Ceron-Noriega A, Ulrich HD, Kappei D, Ketting RF, Butter F. The double-stranded DNA-binding proteins TEBP-1 and TEBP-2 form a telomeric complex with POT-1. Nat Commun 2021 12(1) 2668  [ PubMed ID = 33976151 ] [ RRC reference ] Lister-Shimauchi EH, Dinh M, Maddox P, Ahmed S. Gametes deficient for Pot1 telomere binding proteins alter levels of telomeric foci for multiple generations. Commun Biol 2021 4(1) 158  [ PubMed ID = 33542458 ] [ RRC reference ] Seo B, Kim C, Hills M, Sung S, Kim H, Kim E, Lim DS, Oh HS, Choi RMJ, Chun J, Shim J, Lee J. Telomere maintenance through recruitment of internal genomic regions. Nat Commun 2015 6 8189  [ PubMed ID = 26382656 ] [ RRC reference ] Cook DE, Zdraljevic S, Tanny RE, Seo B, Riccardi DD, Noble LM, Rockman MV, Alkema MJ, Braendle C, Kammenga JE, Wang J, Kruglyak L, Félix MA, Lee J, Andersen EC. The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length. Genetics 2016 204(1) 371-83  [ PubMed ID = 27449056 ] [ RRC reference ] Shtessel L, Lowden MR, Cheng C, Simon M, Wang K, Ahmed S. Caenorhabditis elegans POT-1 and POT-2 repress telomere maintenance pathways. G3 (Bethesda) 2013 3(2) 305-13  [ PubMed ID = 23390606 ] [ RRC reference ] Cheng C, Shtessel L, Brady MM, Ahmed S. Caenorhabditis elegans POT-2 telomere protein represses a mode of alternative lengthening of telomeres with normal telomere lengths. Proc Natl Acad Sci U S A 2012 109(20) 7805-10  [ PubMed ID = 22547822 ] [ RRC reference ] Ferreira HC, Towbin BD, Jegou T, Gasser SM. The shelterin protein POT-1 anchors Caenorhabditis elegans telomeres through SUN-1 at the nuclear periphery. J Cell Biol 2013 203(5) 727-35  [ PubMed ID = 24297748 ] [ RRC reference ] Raices M, Verdun RE, Compton SA, Haggblom CI, Griffith JD, Dillin A, Karlseder J. C. elegans telomeres contain G-strand and C-strand overhangs that are bound by distinct proteins. Cell 2008 132(5) 745-57  [ PubMed ID = 18329362 ] [ RRC reference ]