Mutants (Isolated)

tm1163

Allele Nametm1163
Allele TypeNormal
Sequence NameT23D8.7
Gene Namehpo-24
Worm BaseAllele Name tm1163
Gene Name hpo-24
Sequence T23D8.7
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype" homozygous viable. Dr. C. Mello, Cell 127, 747-457 (2006).
Mutation site Please see gene structure to locate the deletion in relation to exon(s) 28137/28138-28572/28573 (435 bp deletion)
ChromosomeI
Putative gene structurejoin(26949..27068, 27120..27187, 27232..27606, 27661..28621, 28689..28819, 29049..29748, 30273..30464, 30510..30659)
Map position4.14
Balancer
Map position of balancer
Sequence of primersExtFwd:CCGTTTTACCTGATACCGTG,IntFwd:GCCGATGGTCTCTTTGCGTT,ExtRev:GTCTGGTTCTGCGTATCTGA,IntRev:CGGTTATGCCGATATATGCA
Distributed lab
DepositorDr. S. Mitani
References Please submit your publication
Brenner JL, Jyo EM, Mohammad A, Fox P, Jones V, Mardis E, Schedl T, Maine EM.
TRIM-NHL protein, NHL-2, modulates cell fate choices in the C. elegans germ line.
Dev Biol 2022 491 43-55 
[ PubMed ID = 36063869 ] [ RRC reference ]

Toker IA, Lev I, Mor Y, Gurevich Y, Fisher D, Houri-Zeevi L, Antonova O, Doron H, Anava S, Gingold H, Hadany L, Shaham S, Rechavi O.
Transgenerational inheritance of sexual attractiveness via small RNAs enhances evolvability in C. elegans.
Dev Cell 2022 57(3) 298-309.e9 
[ PubMed ID = 35134343 ] [ RRC reference ]

Takagaki N, Ohta A, Ohnishi K, Kawanabe A, Minakuchi Y, Toyoda A, Fujiwara Y, Kuhara A.
The mechanoreceptor DEG-1 regulates cold tolerance in Caenorhabditis elegans.
EMBO Rep 2020 21(3) e48671 
[ PubMed ID = 32009302 ] [ RRC reference ]

Brown KC, Svendsen JM, Tucci RM, Montgomery BE, Montgomery TA.
ALG-5 is a miRNA-associated Argonaute required for proper developmental timing in the Caenorhabditis elegans germline.
Nucleic Acids Res 2017 45(15) 9093-9107 
[ PubMed ID = 28645154 ] [ RRC reference ]

She X, Xu X, Fedotov A, Kelly WG, Maine EM.
Regulation of heterochromatin assembly on unpaired chromosomes during Caenorhabditis elegans meiosis by components of a small RNA-mediated pathway.
PLoS Genet 2009 5(8) e1000624 
[ PubMed ID = 19714217 ] [ RRC reference ]