Home > 分離済み変異体 > tm1037

分離済み変異体

Allele Name		tm1037
Balance		Not Required
OutCross		Not Accepted
Sequence Name		T02G5.8
Gene Name		kat-1
Worm Base	Allele Name	tm1037
	Gene Name	kat-1
	Sequence	T02G5.8
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable. Dr. G. Ruvkun: elevation of Nile Red staining. Dr. H.R. Horvitz: slightly elevated staining with Nile Red dye, which may indicate increased lipid accumulation. Dr. Y-K. Paik: dauer formed on daumone plate. Dr. K. Ashrafi: increased Nile Red staining.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		4693/4694-AGAGAAGACTTCAAAAGAAATGGGAATTG-5210/5211 (517 bp deletion + 29 bp insertion)
Chromosome		II
Putative gene structure		join(4483..4692, 4795..5058, 5155..5307, 5358..5493, 5543..5882, 5957..6077)
Map position		0.49
Balancer
Map position of balancer
Sequence of primers		IntRev:CCATGTGGGTTCACAAGGGA,ExtRev:GCAACATACCCGATGGGGTG,IntFwd:TAGGAGTATCGAAACCGCCA,ExtFwd:AGGAGCTCCTAGGAGTATCG
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Labarre A, Guitard E, Tossing G, Forest A, Bareke E, Labrecque M, Tétreault M, Ruiz M, Alex Parker J. Fatty acids derived from the probiotic Lacticaseibacillus rhamnosus HA-114 suppress age-dependent neurodegeneration. Commun Biol 2022 5(1) 1340  [ PubMed ID = 36477191 ] [ RRC reference ] Midkiff DF, Huayta J, Lichty JD, Crapster JP, San-Miguel A. Identifying C. elegans lifespan mutants by screening for early-onset protein aggregation. iScience 2022 25(11) 105460  [ PubMed ID = 36388964 ] [ RRC reference ] Park S, Paik YK. Genetic deficiency in neuronal peroxisomal fatty acid β-oxidation causes the interruption of dauer development in Caenorhabditis elegans. Sci Rep 2017 7(1) 9358  [ PubMed ID = 28839231 ] [ RRC reference ] Barros AG, Bridi JC, de Souza BR, de Castro Júnior C, de Lima Torres KC, Malard L, Jorio A, de Miranda DM, Ashrafi K, Romano-Silva MA. Dopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans. PLoS One 2014 9(1) e85874  [ PubMed ID = 24465759 ] [ RRC reference ] Berdichevsky A, Nedelcu S, Boulias K, Bishop NA, Guarente L, Horvitz HR. 3-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1. Proc Natl Acad Sci U S A 2010 107(44) 18927-32  [ PubMed ID = 20956318 ] [ RRC reference ] Mak HY, Nelson LS, Basson M, Johnson CD, Ruvkun G. Polygenic control of Caenorhabditis elegans fat storage. Nat Genet 2006 38(3) 363-8  [ PubMed ID = 16462744 ] [ RRC reference ]