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分離済み変異体

Allele Name		tm1037
Allele Type		通常株
Sequence Name		T02G5.8
Gene Name		kat-1
Worm Base	Allele Name	tm1037
	Gene Name	kat-1
	Sequence	T02G5.8
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable. Dr. G. Ruvkun: elevation of Nile Red staining. Dr. H.R. Horvitz: slightly elevated staining with Nile Red dye, which may indicate increased lipid accumulation. Dr. Y-K. Paik: dauer formed on daumone plate. Dr. K. Ashrafi: increased Nile Red staining.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		4693/4694-AGAGAAGACTTCAAAAGAAATGGGAATTG-5210/5211 (517 bp deletion + 29 bp insertion)
Chromosome		II
Putative gene structure		join(4483..4692, 4795..5058, 5155..5307, 5358..5493, 5543..5882, 5957..6077)
Map position		0.49
Balancer
Map position of balancer
Sequence of primers		IntRev:CCATGTGGGTTCACAAGGGA,ExtRev:GCAACATACCCGATGGGGTG,IntFwd:TAGGAGTATCGAAACCGCCA,ExtFwd:AGGAGCTCCTAGGAGTATCG
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Midkiff DF, Huayta J, Lichty JD, Crapster JP, San-Miguel A. Identifying C. elegans lifespan mutants by screening for early-onset protein aggregation. iScience 2022 25(11) 105460  [ PubMed ID = 36388964 ] [ RRC reference ] Labarre A, Guitard E, Tossing G, Forest A, Bareke E, Labrecque M, Tétreault M, Ruiz M, Alex Parker J. Fatty acids derived from the probiotic Lacticaseibacillus rhamnosus HA-114 suppress age-dependent neurodegeneration. Commun Biol 2022 5(1) 1340  [ PubMed ID = 36477191 ] [ RRC reference ] Park S, Paik YK. Genetic deficiency in neuronal peroxisomal fatty acid β-oxidation causes the interruption of dauer development in Caenorhabditis elegans. Sci Rep 2017 7(1) 9358  [ PubMed ID = 28839231 ] [ RRC reference ] Berdichevsky A, Nedelcu S, Boulias K, Bishop NA, Guarente L, Horvitz HR. 3-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1. Proc Natl Acad Sci U S A 2010 107(44) 18927-32  [ PubMed ID = 20956318 ] [ RRC reference ] Barros AG, Bridi JC, de Souza BR, de Castro Júnior C, de Lima Torres KC, Malard L, Jorio A, de Miranda DM, Ashrafi K, Romano-Silva MA. Dopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans. PLoS One 2014 9(1) e85874  [ PubMed ID = 24465759 ] [ RRC reference ] Mak HY, Nelson LS, Basson M, Johnson CD, Ruvkun G. Polygenic control of Caenorhabditis elegans fat storage. Nat Genet 2006 38(3) 363-8  [ PubMed ID = 16462744 ] [ RRC reference ]