Strain Name: towhead / Allele: rw685

Allele rw685
Strain Name towhead
Type Mutant
Affected Gene GDP-D-mannose 4,6-dehydratase (gmds)
Origin and Depositor RIKEN CBS (Hitoshi Okamoto)
Link to ZFIN
Fucosylated glycans are involved in a variety of biological and pathological processes, including cell migration. The donor substrate for fucosylation, GDP-fucose, is synthesized in the cytoplasm mainly through a de novo synthesis pathway, which includes an enzymatic reaction catalyzed by GDP-mannose 4,6-dehydrase (GMDS). The towhead mutant has a mis-sense mutation in gmds and affects the expression of fucosylated glycans. Known phenotypes; viability (leathal, 6-7 days post-fertilization), neural migration (the trigeminal, the facial, and the vagus motor neurons), 'curled up' tail.  
The Conditions to Distribute Strains
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Ohata S., et al. (2009) Neuroepithelial cells require fucosylated glycans to guide the migration of vagus motor neuron progenitors in the developing zebrafish hindbrain. Development 136, 1653-1663,  
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Facility RIKEN (Wako) CBS, Lab for Neural Circuit Dynamics of Decision Making