Strain Name: Tg(fli1a:YFP-DEVD-CFP)
|Origin and Depositor||National Cerebral and Cardiovascular Center Research Institute (Naoki Mochizuki)|
|Link to ZFIN|
|This line expresses a FRET-based caspase sensor, YFP-DEVD-CFP, specifically in endothelial cells by fli1a promoter. In YFP-DEVD-CFP, CFP is fused with YFP by a caspase-sensitive amino acid peptide (DEVD). Upon induction of apoptosis, FRET is interrupted due to cleavage of the linker by caspase-3. Therefore, loss of FRET becomes a direct indicator of caspase activity.|
|The Conditions to Distribute Strains|
Use of the BIOLOGICAL RESOURCE shall be limited to a collaborative research with the DEPOSITOR.
Prior to filing an application for a patent, or intellectual property or other rights based on the results of research using the BIOLOGICAL RESOURCE, the recipient shall acquire the consent from (or notify to) the DEPOSITOR for such application.
Prior to publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, the recipient shall acquire the consent from the DEPOSITOR.
|Facility||RIKEN (Wako) CBS, Lab for Neural Circuit Dynamics of Decision Making|