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Reference Detail
| Reference | ||
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| Author | Lu M., He Q., Wang G., Fan Q., Yan W., Gu K., Yang Z., Du J., Xie K., Li L., Zhang H., Chen J., Sun Z., Li Y. | |
| Title | JA-responsive R2R3-type MYB transcription factor osmyb4p confers broad-spectrum antiviral immunity in rice. | |
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Abstract: Jasmonic acid (JA) plays a critical role in antiviral defence in rice, where viral infection activates JA signalling by degrading Jasmonate ZIM domain (JAZ) proteins, thereby releasing transcription factors (TFs) to drive JA-mediated defence gene expression. While the JA-responsive TF OsMYC2 has been extensively studied in rice, the involvement of MYB TFs in JA signalling remains largely unexplored. In this study, we identified a novel JA-responsive R2R3-type MYB TF osmyb4p. osmyb4p functions as a transcriptional activator, activating the expression of the JA synthesis gene CM-LOX1, and positively regulating rice sensitivity to JA. Additionally, osmyb4p interacts with OsJAZs and is subject to transcriptional inhibition by OsJAZs. Overexpression of osmyb4p (OE-osmyb4p) enhances rice resistance to viral infection, whereas knockout mutants (osmyb4p) exhibit increased susceptibility. Further studies revealed that viral proteins SP8 and P2, encoded by southern rice black-streaked dwarf virus (SRBSDV) and rice stripe virus (RSV), respectively, disrupt osmyb4p self-interaction. This interference reduces osmyb4p protein stability, transcriptional activation and DNA binding ability, thereby suppressing JA signalling and facilitating the viral infection. Overall, our findings demonstrate that the JA-responsive R2R3-type MYB TF osmyb4p, as a direct target of JAZs, plays a key role in JA signalling and contributes to broad-spectrum antiviral defence in rice. |
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| Journal | Plant Biotechnol. J. | |
| Country | China | |
| Volume | 23(10) | |
| Pages | 4602-4617 | |
| Year | 2025 | |
| PubMed ID | 40652551 | |
| PubMed Central ID | 12483970 | |
| DOI | 10.1111/pbi.70246 | |
| URL | - | |
| Relation | ||
| Gene | MYB4P TIFY10A TIFY11A TIFY11C TIFY6B _ | |
| INSD | - | |
| Strain | Wild Core Collection | - |
| Induced Mutation Lines(NIG Collection) | - | |
| Sterile Seed Strain | - | |
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Lethal Embryo Mutantion Strain |
- | |
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Stages in Each Organ - Muant Lines (Gene) |
- | |
| Cultivated Varieties(NIG Collection) | - | |
| Stages in Each Organ | - | |
