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Author Rahman M.M., Seo D.Y., Rahman M.M., Huang C.Y., Ogawa A., Beaurepère T., Aung M.S., Ouerdane L., Song W.Y., Lee S., An G., Jeon J.S.
Title Toward Nutrient-Rich Rice: Biofortification through Mineral Accumulation and Low Phytic Acid Content.
Abstract:
Nicotianamine synthases regulate the biosynthesis of two mineral chelators key for rice grain biofortification, nicotianamine (NA) and 2'-deoxymugineic acid (DMA). We produced transgenic rice expressing <i>OsNAS2</i> under the <i>OsRCc3</i> promoter (<i>RcN2</i>) and mutated <i>OsLpa1</i> in these (<i>lpa1 RcN2</i>) and the wild-type (<i>lpa1</i>) to enhance essential mineral accumulation in grains while lowering phytic acid (PA) levels. NA and DMA contents were higher in the brown grains of <i>RcN2</i>, <i>lpa1 RcN2</i>, and <i>lpa1</i> plants. The grains of these lines accumulated increased levels of essential minerals, with <i>lpa1 RcN2</i> exhibiting the greatest increases. PA-bound iron and zinc levels were lower in <i>lpa1</i> and <i>lpa1 RcN2</i> grains, while NA- and DMA-bound iron and zinc levels were higher in <i>RcN2</i>, <i>lpa1 RcN2</i>, and <i>lpa1</i> grains. Field-grown <i>RcN2</i> plants showed no significant growth penalties, unlike <i>lpa1</i> and <i>lpa1 RcN2</i>. Furthermore, <i>lpa1</i> and <i>lpa1 RcN2</i> grains were chalky, a property that facilitates rice flour production.
Journal J. Agric. Food Chem.
Country South Korea
Volume 73(38)
Pages 24262-24277
Year 2025
PubMed ID 40899499
PubMed Central ID 12464976
DOI 10.1021/acs.jafc.5c06403
URL -
Relation
Gene LPA1 NAS2
INSD -
Strain Wild Core Collection -
Induced Mutation Lines(NIG Collection) -
Sterile Seed Strain -
Lethal Embryo
Mutantion Strain 		-
Stages in Each Organ
- Muant Lines (Gene) 		-
Cultivated Varieties(NIG Collection) -
Stages in Each Organ -
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