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Reference Detail
| Reference | ||
|---|---|---|
| Author | Li X.K., Huang Y.H., Zhao R., Cao W.Q., Lu L., Han J.Q., Zhou Y., Zhang X., Wu W.A., Tao J.J., Wei W., Zhang W.K., Chen S.Y., Ma B., Zhao H., Yin C.C., Zhang J.S. | |
| Title | Membrane protein MHZ3 regulates the on-off switch of ethylene signaling in rice. | |
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Abstract: Ethylene regulates plant growth, development, and stress adaptation. However, the early signaling events following ethylene perception, particularly in the regulation of ethylene receptor/CTRs (CONSTITUTIVE TRIPLE RESPONSE) complex, remains less understood. Here, utilizing the rapid phospho-shift of rice OsCTR2 in response to ethylene as a sensitive readout for signal activation, we revealed that MHZ3, previously identified as a stabilizer of ETHYLENE INSENSITIVE 2 (OsEIN2), is crucial for maintaining OsCTR2 phosphorylation. Genetically, both functional MHZ3 and ethylene receptors prove essential for OsCTR2 phosphorylation. MHZ3 physically interacts with both subfamily I and II ethylene receptors, e.g., OsERS2 and OsETR2 respectively, stabilizing their association with OsCTR2 and thereby maintaining OsCTR2 activity. Ethylene treatment disrupts the interactions within the protein complex MHZ3/receptors/OsCTR2, reducing OsCTR2 phosphorylation and initiating downstream signaling. Our study unveils the dual role of MHZ3 in fine-tuning ethylene signaling activation, providing insights into the initial stages of the ethylene signaling cascade. |
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| Journal | Nat Commun | |
| Country | China | |
| Volume | 15(1) | |
| Pages | 5987 | |
| Year | 2024 | |
| PubMed ID | 39013913 | |
| PubMed Central ID | 11252128 | |
| DOI | 10.1038/s41467-024-50290-4 | |
| URL | - | |
| Relation | ||
| Gene | CTR2 EIN2 ERS2 ETR2 MHZ3 | |
| INSD | - | |
| Strain | Wild Core Collection | - |
| Induced Mutation Lines(NIG Collection) | - | |
| Sterile Seed Strain | - | |
|
Lethal Embryo Mutantion Strain |
- | |
|
Stages in Each Organ - Muant Lines (Gene) |
- | |
| Cultivated Varieties(NIG Collection) | - | |
| Stages in Each Organ | - | |
