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Reference Detail
| Reference | ||
|---|---|---|
| Author | Shen S.Y., Ma M., Bai C., Wang W.Q., Zhu R.B., Gao Q., Song X.J. | |
| Title | Optimizing rice grain size.by attenuating phosphorylation-triggered functional impairment of a chromatin modifier ternary complex. | |
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Abstract: Histone acetylation affects numerous cellular processes, such as gene transcription, in both plants and animals. However, the posttranslational modification-participated regulatory networks for crop-yield-related traits are largely unexplored. Here, we characterize a regulatory axis for controlling rice grain size.and yield, centered on a potent histone acetyltransferase (chromatin modifier) known as HHC4. HHC4 interacts with and forms a ternary complex with adaptor protein ADA2 and transcription factor bZIP23, wherein bZIP23 recruits HHC4 to specific promoters, and ADA2 and HHC4 additively enhance bZIP23 transactivation on target genes. Meanwhile, HHC4 interacts with and is phosphorylated by GSK3-like kinase TGW3. The resultant phosphorylation triggers several functional impairments of the HHC4 ternary complex. In addition, we identify two major phosphorylation sites of HHC4 by TGW3-sites which play an important role in controlling rice grain size. Overall, our findings thus have critical implications for understanding epigenetic basis of grain size.control and manipulating the knowledge for higher crop productivity. |
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| Journal | Dev. Cell | |
| Country | China | |
| Volume | 59(4) | |
| Pages | 448-464.e8 | |
| Year | 2024 | |
| PubMed ID | 38237589 | |
| PubMed Central ID | - | |
| DOI | 10.1016/j.devcel.2023.12.013 | |
| URL | - | |
| Relation | ||
| Gene | BZIP23 GNAT2 HHC3 HHC7 HXA701 NAA10 TGW3 | |
| INSD | - | |
| Strain | Wild Core Collection | - |
| Induced Mutation Lines(NIG Collection) | - | |
| Sterile Seed Strain | - | |
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Lethal Embryo Mutantion Strain |
- | |
|
Stages in Each Organ - Muant Lines (Gene) |
- | |
| Cultivated Varieties(NIG Collection) | - | |
| Stages in Each Organ | - | |
