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Author Huang Y.H., Han J.Q., Ma B., Cao W.Q., Li X.K., Xiong Q., Zhao H., Zhao R., Zhang X., Zhou Y., Wei W., Tao J.J., Zhang W.K., Qian W., Chen S.Y., Yang C., Yin C.C., Zhang J.S.
Title A translational regulator MHZ9 modulates ethylene signaling in rice.
Abstract:
Ethylene plays essential roles in rice growth, development and stress adaptation. Translational control of ethylene signaling remains unclear in rice. Here, through analysis of an ethylene-response mutant MHZ9, we identified a glycine-tyrosine-phenylalanine (GYF) domain protein MHZ9, which positively regulates ethylene signaling at translational level in rice. MHZ9 is localized in RNA processing bodies. The C-terminal domain of MHZ9 interacts with OsEIN2, a central regulator of rice ethylene signaling, and the N-terminal domain directly binds to the OsEBF1/2 mRNAs for translational inhibition, allowing accumulation of transcription factor OsEIL1 to activate the downstream signaling. RNA-IP seq and CLIP-seq analyses reveal that MHZ9 associates with hundreds of RNAs. Ribo-seq analysis indicates that MHZ9 is required for the regulation of ~ 90% of genes translationally affected by ethylene. Our study identifies a translational regulator MHZ9, which mediates translational regulation of genes in response to ethylene, facilitating stress adaptation and trait improvement in rice.
Journal Nat Commun
Country China
Volume 14(1)
Pages 4674
Year 2023
PubMed ID 37542048
PubMed Central ID 10403538
DOI 10.1038/s41467-023-40429-0
URL -
Relation
Gene CRW1 DCP2 EIL1 EIL2 EIN2 EIN5 ERS2 FBOX72 MHZ9
INSD -
Strain Wild Core Collection -
Induced Mutation Lines(NIG Collection) -
Sterile Seed Strain -
Lethal Embryo
Mutantion Strain 		-
Stages in Each Organ
- Muant Lines (Gene) 		-
Cultivated Varieties(NIG Collection) -
Stages in Each Organ -
/rice/oryzabase