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Author Gong F., Zhang K., Wen J., Yu S., Li W., Du G., Wu C., Zhu K., Xu Y.
Title Rice OsMRG702 and Its Partner OsMRGBP Control flowering time through H4 Acetylation.
Abstract:
MORF-RELATED GENE702 (OsMRG702) regulates flowering time genes in rice, but how it controls transcription is not well known. Here, we found that OsMRGBP can directly interact with OsMRG702. Both <i>OsMRG702</i> and <i>OsMRGBP</i> mutants show the delayed flowering phenotype with the reduction in the transcription of multiple key flowering time genes, including <i>Ehd1</i> and <i>RFT1</i>. Chromatin immunoprecipitation study showed that both OsMRG702 and OsMRGBP bind to the <i>Ehd1</i> and <i>RFT1</i> loci and the absence of either OsMRG702 or OsMRGBP leads to a decrease of H4K5 acetylation at these loci, indicating OsMRG702 and OsMRGBP cooperatively together to promote the H4K5 acetylation. In addition, whilst <i>Ghd7</i> are upregulated in both <i>OsMRG702</i> and <i>OsMRGBP</i> mutants, only OsMRG702 binds to the loci, together with the global increased and <i>Ghd7</i> locus-specific increased H4K5ac levels in <i>OsMRG702</i> mutants, suggesting an additional negative effect of OsMRG702 on H4K5 acetylation. In summary, OsMRG702 controls flowering gene regulation by altering H4 acetylation in rice; it works either together with OsMRGBP to enhance transcription by promoting H4 acetylation or with other unknown mechanisms to dampen transcription by preventing H4 acetylation.
Journal Int J Mol Sci
Country China
Volume 24(11)
Pages
Year 2023
PubMed ID 37298171
PubMed Central ID 10252469
DOI 10.3390/ijms24119219
URL -
Relation
Gene EF1 EHD3 GHD7 HD3A MRG702 MRGBP RFT1
INSD -
Strain Wild Core Collection -
Induced Mutation Lines(NIG Collection) -
Sterile Seed Strain -
Lethal Embryo
Mutantion Strain 		-
Stages in Each Organ
- Muant Lines (Gene) 		-
Cultivated Varieties(NIG Collection) -
Stages in Each Organ -
/rice/oryzabase