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Reference Detail
| Reference | ||
|---|---|---|
| Author | Tang J., Wang Y., Yin W., Dong G., Sun K., Teng Z., Wu X., Wang S., Qian Y., Pan X., Qian Q., Chu C. | |
| Title | Mutation of a Nucleotide-Binding Leucine-Rich Repeat Immune Receptor-Type Protein Disrupts Immunity to Bacterial Blight. | |
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Abstract: Most characterized plant resistance proteins belong to the nucleotide-binding domain and Leu-rich repeat-containing (NLR) family. NLRs are present in an auto-inhibited state in the absence of specific pathogens, while gain-of-function mutations in NLRs usually cause autoimmunity. Here, we show that a gain-of-function mutation, <i>weaker defense</i> (<i>wed</i>), which caused a Phe-to-Leu substitution in the nucleotide-binding domain of a typical NLR in rice (<i>Oryza sativa</i>), led to enhanced susceptibility to <i>Xanthomonas oryzae</i> pv. <i>Oryzae</i> The unexpected accumulation of salicylic acid (SA), along with downregulation of <i>NONEXPRESSOR OF PR1</i> (<i>NPR1</i>), in <i>wed</i> indicates the potential presence of a feedback regulation loop of SA biosynthesis in rice. Epistasis analyses illustrated that SA accumulation and the NLR-associated components RAR1, OsRac1, and PhyB are dispensable for the <i>wed</i> phenotypes. Intriguingly, besides pattern-triggered immunity, effector-triggered immunity conferred by different resistance proteins, including Xa3/Xa26, Xa4, and Xa21, was also disturbed by <i>wed</i> to a certain extent, indicating the existence of shared regulatory mechanisms for various defense systems. The identification of <i>wed</i> therefore provides a unique system for genetic dissection of shared immune signaling pathways activated by different types of immune receptors. |
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| Journal | Plant Physiol. | |
| Country | China | |
| Volume | 181(3) | |
| Pages | 1295-1313 | |
| Year | 2019 | |
| PubMed ID | 31431512 | |
| PubMed Central ID | 6836841 | |
| DOI | 10.1104/pp.19.00686 | |
| URL | - | |
| Relation | ||
| Gene | AOS2 JIOSPR10 NH1 PHYB PR10A PR1A PR5 RAC1 RAR1 WED XA21 XA3 XA4 _ | |
| INSD | - | |
| Strain | Wild Core Collection | - |
| Induced Mutation Lines(NIG Collection) | - | |
| Sterile Seed Strain | - | |
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Lethal Embryo Mutantion Strain |
- | |
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Stages in Each Organ - Muant Lines (Gene) |
- | |
| Cultivated Varieties(NIG Collection) | - | |
| Stages in Each Organ | - | |
