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Reference Detail
| Reference | ||
|---|---|---|
| Author | Hu B., Jiang Z., Wang W., Qiu Y., Zhang Z., Liu Y., Li A., Gao X., Liu L., Qian Y., Huang X., Yu F., Kang S., Wang Y., Xie J., Cao S., Zhang L., Wang Y., Xie Q., Kopriva S., Chu C. | |
| Title | Nitrate-NRT1.1B-SPX4 cascade integrates nitrogen and phosphorus signalling networks in plants. | |
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Abstract: To ensure high crop yields in a sustainable manner, a comprehensive understanding of the control of nutrient acquisition is required. In particular, the signalling networks controlling the coordinated utilization of the two most highly demanded mineral nutrients, nitrogen and phosphorus, are of utmost importance. Here, we reveal a mechanism by which nitrate activates both phosphate and nitrate utilization in rice (Oryza sativa L.). We show that the nitrate sensor NRT1.1B interacts with a phosphate signalling repressor SPX4. Nitrate perception strengthens the NRT1.1B-SPX4 interaction and promotes the ubiquitination and degradation of SPX4 by recruiting NRT1.1B interacting protein 1 (NBIP1), an E3 ubiquitin ligase. This in turn allows the key transcription factor of phosphate signalling, PHR2, to translocate to the nucleus and initiate the transcription of phosphorus utilization genes. Interestingly, the central transcription factor of nitrate signalling, NLP3, is also under the control of SPX4. Thus, nitrate-triggered degradation of SPX4 activates both phosphate- and nitrate-responsive genes, implementing the coordinated utilization of nitrogen and phosphorus. |
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| Journal | Nat Plants | |
| Country | China | |
| Volume | 5(4) | |
| Pages | 401-413 | |
| Year | 2019 | |
| PubMed ID | 30911122 | |
| PubMed Central ID | - | |
| DOI | 10.1038/s41477-019-0384-1 | |
| URL | - | |
| Relation | ||
| Gene | IPS1 NBIP1 NLP3 NPF6.5 NRT2.1 PAP10A PHR2 PI1 PSR1 PT10 PT13 PT2 PT3 PT6 PT8 RNS3 SPX4 _ | |
| INSD | - | |
| Strain | Wild Core Collection | - |
| Induced Mutation Lines(NIG Collection) | - | |
| Sterile Seed Strain | - | |
|
Lethal Embryo Mutantion Strain |
- | |
|
Stages in Each Organ - Muant Lines (Gene) |
- | |
| Cultivated Varieties(NIG Collection) | - | |
| Stages in Each Organ | - | |
