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著者 Simeon O Kotchoni, Jose C Jimenez-Lopez, Gao D., Edwards V., Emma W Gachomo, Venu M Margam, Manfredo J Seufferheld
タイトル Modeling-dependent protein characterization of the rice aldehyde dehydrogenase (ALDH) superfamily reveals distinct functional and structural features.
Abstract:
The completion of the rice genome sequence has made it possible to identify and characterize new genes and to perform comparative genomics studies across taxa. The aldehyde dehydrogenase (ALDH) gene superfamily encoding for NAD(P)(+)-dependent enzymes is found in all major plant and animal taxa. However, the characterization of plant ALDHs has lagged behind their animal- and prokaryotic-ALDH homologs. In plants, ALDHs are involved in abiotic stress tolerance, male sterility restoration, embryo development and seed viability and maturation. However, there is still no structural property-dependent functional characterization of ALDH protein superfamily in plants. In this paper, we identify members of the rice ALDH gene superfamily and use the evolutionary nesting events of retrotransposons and protein-modeling-based structural reconstitution to report the genetic and molecular and structural features of each member of the rice ALDH superfamily in abiotic/biotic stress responses and developmental processes. Our results indicate that rice-ALDHs are the most expanded plant ALDHs ever characterized. This work represents the first report of specific structural features mediating functionality of the whole families of ALDHs in an organism ever characterized.
掲載誌 PLoS ONE
Country USA
刊数 5(7)
ページ e11516
発刊年 2010
PubMed ID 20634950
PubMed Central ID 2902511
DOI 10.1371/journal.pone.0011516
URL -
関連情報
遺伝子 ALDH11A3 ALDH12B1 ALDH18B2 ALDH1A ALDH22A1 ALDH2A ALDH2B1 ALDH2B2 ALDH2C1 ALDH3B1 ALDH3E1 ALDH3E2 ALDH3H1 ALDH3H2 ALDH5F1 ALDH6B2 ALDH7 BAD1 P5CS SK2(T)(SCL, FGR) _
INSD -
系統 野生イネ
コアコレクション 		-
突然変異系統(遺伝研 Collection) -
種子不稔系統 -
致死変異体系統 -
組織別発生段階
- 突然変異系統(遺伝子) 		-
栽培イネ品種(遺伝研 Collection) -
組織別発生段階 -
/rice/oryzabase