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Reference Detail
| Reference | ||
|---|---|---|
| Author | Park C.H., Shirsekar G., Bellizzi M., Chen S., Songkumarn P., Xie X., Shi X., Ning Y., Zhou B., Suttiviriya P., Wang M., Umemura K., Wang G.L. | |
| Title | The E3 ligase APIP10 Connects the Effector AvrPiz-t to the NLR receptor Piz-t in Rice. | |
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Abstract: Although nucleotide-binding domain, leucine-rich repeat (NLR) proteins are the major immune receptors in plants, the mechanism that controls their activation and immune signaling remains elusive. Here, we report that the avirulence effector AvrPiz-t from Magnaporthe oryzae targets the rice E3 ligase APIP10 for degradation, but that APIP10, in return, ubiquitinates AvrPiz-t and thereby causes its degradation. Silencing of APIP10 in the non-Piz-t background compromises the basal defense against M. oryzae. Conversely, silencing of APIP10 in the Piz-t background causes cell death, significant accumulation of Piz-t, and enhanced resistance to M. oryzae, suggesting that APIP10 is a negative regulator of Piz-t. We show that APIP10 promotes degradation of Piz-t via the 26S proteasome system. Furthermore, we demonstrate that AvrPiz-t stabilizes Piz-t during M. oryzae infection. Together, our results show that APIP10 is a novel E3 ligase that functionally connects the fungal effector AvrPiz-t to its NLR receptor Piz-t in rice. |
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| Journal | PLoS Pathog. | |
| Country | USA | |
| Volume | 12(3) | |
| Pages | e1005529 | |
| Year | 2016 | |
| PubMed ID | 27031246 | |
| PubMed Central ID | 4816579 | |
| DOI | 10.1371/journal.ppat.1005529 | |
| URL | - | |
| Relation | ||
| Gene | APIP10 KS4 PAL1 PIZT | |
| INSD | - | |
| Strain | Wild Core Collection | - |
| Induced Mutation Lines(NIG Collection) | - | |
| Sterile Seed Strain | - | |
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Lethal Embryo Mutantion Strain |
- | |
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Stages in Each Organ - Muant Lines (Gene) |
- | |
| Cultivated Varieties(NIG Collection) | - | |
| Stages in Each Organ | - | |
