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| 文献 | ||
|---|---|---|
| 著者 | Zhang H., Lu Y., Zhao Y., Zhou D.X. | |
| タイトル | OsSRT1 is involved in rice seed development through regulation of starch metabolism gene expression. | |
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Abstract: OsSRT1 is a NAD(+)-dependent histone deacetylase, closely related to the human SIRT6 that plays key roles in genome stability and metabolic homeostasis. In this work, we investigated the role of OsSRT1 in rice seed development. Down-regulation of OsSRT1 induced higher expression of Rice Starch Regulator1 (RSR1) and amylases genes in developing seeds, which resulted in a decrease of starch synthesis and an increase of starch degradation, leading to abnormal seed development. ChIP assay showed that OsSRT1 was required to reduce histone H3K9 acetylation on starch metabolism genes and transposons in developing seeds. In addition, OsSRT1 was detected to directly bind to starch metabolism genes such as OsAmy3B, OsAmy3E, OsBmy4, and OsBmy9. Our results suggested that OsSRT1-mediated histone deacetylation is involved in starch accumulation and transposon repression to regulate normal seed development. |
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| 掲載誌 | Plant Sci. | |
| Country | unknown | |
| 刊数 | 248 | |
| ページ | 28-36 | |
| 発刊年 | 2016 | |
| PubMed ID | 27181944 | |
| PubMed Central ID | - | |
| DOI | 10.1016/j.plantsci.2016.04.004 | |
| URL | - | |
| 関連情報 | ||
| 遺伝子 | HDAC10 HDAC6 RSR1 SRT701 | |
| INSD | - | |
| 系統 |
野生イネ コアコレクション |
- |
| 突然変異系統(遺伝研 Collection) | - | |
| 種子不稔系統 | - | |
| 致死変異体系統 | - | |
|
組織別発生段階 - 突然変異系統(遺伝子) |
- | |
| 栽培イネ品種(遺伝研 Collection) | - | |
| 組織別発生段階 | - | |
