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| 文献 | ||
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| 著者 | Chen W., Gao Y., Xie W., Gong L., Lu K., Wang W., Li Y., Liu X., Zhang H., Dong H., Zhang W., Zhang L., Yu S., Wang G., Lian X., Luo J. | |
| タイトル | Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism. | |
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Abstract: Plant metabolites are important to world food security in terms of maintaining sustainable yield and providing food with enriched phytonutrients. Here we report comprehensive profiling of 840 metabolites and a further metabolic genome-wide association study based on ∼6.4 million SNPs obtained from 529 diverse accessions of Oryza sativa. We identified hundreds of common variants influencing numerous secondary metabolites with large effects at high resolution. We observed substantial heterogeneity in the natural variation of metabolites and their underlying genetic architectures among different subspecies of rice. Data mining identified 36 candidate genes modulating levels of metabolites that are of potential physiological and nutritional importance. As a proof of concept, we functionally identified or annotated five candidate genes influencing metabolic traits. Our study provides insights into the genetic and biochemical bases of rice metabolome variation and can be used as a powerful complementary tool to classical phenotypic trait mapping for rice improvement. |
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| 掲載誌 | Nat. Genet. | |
| Country | unknown | |
| 刊数 | 46(7) | |
| ページ | 714-21 | |
| 発刊年 | 2014 | |
| PubMed ID | 24908251 | |
| PubMed Central ID | - | |
| DOI | 10.1038/ng.3007 | |
| URL | - | |
| 関連情報 | ||
| 遺伝子 | AHT2 ATASE1 C COMT7 COMTL4 CYP51G3 CYP71C3 CYP72A1 CYP76M7 GAUT17 NOMT PDX1.3A PDX1.3B TBT2 TDC6 TPS29 UGT706D1 UGT707A2 UGT72F1 _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ | |
| INSD | - | |
| 系統 |
野生イネ コアコレクション |
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| 突然変異系統(遺伝研 Collection) | - | |
| 種子不稔系統 | - | |
| 致死変異体系統 | - | |
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組織別発生段階 - 突然変異系統(遺伝子) |
- | |
| 栽培イネ品種(遺伝研 Collection) | - | |
| 組織別発生段階 | - | |
