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Reference Detail
| Reference | ||
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| Author | Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jakab S., Zheng C., Zhong Y. | |
| Title | Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis. | |
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Abstract: The protein phosphatase 2Cs (PP2Cs) from various organisms have been implicated to act as negative modulators of protein kinase pathways involved in diverse environmental stress responses and developmental processes. A genome-wide overview of the PP2C gene family in plants is not yet available. A comprehensive computational analysis identified 80 and 78 PP2C genes in Arabidopsis thaliana (AtPP2Cs) and Oryza sativa (OsPP2Cs), respectively, which denotes the PP2C gene family as one of the largest families identified in plants. Phylogenic analysis divided PP2Cs in Arabidopsis and rice into 13 and 11 subfamilies, respectively, which are supported by the analyses of gene structures and protein motifs. Comparative analysis between the PP2C genes in Arabidopsis and rice identified common and lineage-specific subfamilies and potential 'gene birth-and-death' events. Gene duplication analysis reveals that whole genome and chromosomal segment duplications mainly contributed to the expansion of both OsPP2Cs and AtPP2Cs, but tandem or local duplication occurred less frequently in Arabidopsis than rice. Some protein motifs are widespread among the PP2C proteins, whereas some other motifs are specific to only one or two subfamilies. Expression pattern analysis suggests that 1) most PP2C genes play functional roles in multiple tissues in both species, 2) the induced expression of most genes in subfamily A by diverse stimuli indicates their primary role in stress tolerance, especially ABA response, and 3) the expression pattern of subfamily D members suggests that they may constitute positive regulators in ABA-mediated signaling pathways. The analyses of putative upstream regulatory elements by two approaches further support the functions of subfamily A in ABA signaling, and provide insights into the shared and different transcriptional regulation machineries in dicots and monocots. This comparative genome-wide overview of the PP2C family in Arabidopsis and rice provides insights into the functions and regulatory mechanisms, as well as the evolution and divergence of the PP2C genes in dicots and monocots. Bioinformatics analyses suggest that plant PP2C proteins from different subfamilies participate in distinct signaling pathways. Our results have established a solid foundation for future studies on the functional divergence in different PP2C subfamilies. |
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| Journal | BMC Genomics | |
| Country | China | |
| Volume | 9 | |
| Pages | 550 | |
| Year | 2008 | |
| PubMed ID | 19021904 | |
| PubMed Central ID | 2612031 | |
| DOI | 10.1186/1471-2164-9-550 | |
| URL | - | |
| Relation | ||
| Gene | ABI1 ABI2 DCW11 PP2C1 PP2C1 PP2C10 PP2C11 PP2C12 PP2C14 PP2C15 PP2C16 PP2C17 PP2C18 PP2C19 PP2C2 PP2C20 PP2C21 PP2C22 PP2C23 PP2C24 PP2C25 PP2C26 PP2C27 PP2C28 PP2C29 PP2C30 PP2C31 PP2C32 PP2C33 PP2C34 PP2C36 PP2C37 PP2C38 PP2C39 PP2C4 PP2C40 PP2C41 PP2C42 PP2C43 PP2C44 PP2C45 PP2C46 PP2C47 PP2C48 PP2C49 PP2C5 PP2C50 PP2C52 PP2C53 PP2C54 PP2C55 PP2C56 PP2C57 PP2C58 PP2C59 PP2C6 PP2C61 PP2C62 PP2C63 PP2C64 PP2C65 PP2C66 PP2C67 PP2C69 PP2C7 PP2C70 PP2C71 PP2C72 PP2C73 PP2C74 PP2C75 PP2C77 PP2C78 PP2C8 PP2C9 SAL1 XA46 XB15 | |
| INSD | - | |
| Strain | Wild Core Collection | - |
| Induced Mutation Lines(NIG Collection) | - | |
| Sterile Seed Strain | - | |
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Lethal Embryo Mutantion Strain |
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Stages in Each Organ - Muant Lines (Gene) |
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| Cultivated Varieties(NIG Collection) | - | |
| Stages in Each Organ | - | |
