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Reference Detail
| Reference | ||
|---|---|---|
| Author | Jia L., Michael T Clegg, Jiang T. | |
| Title | Evolutionary dynamics of the DNA-binding domains in putative R2R3-MYB genes identified from rice subspecies indica and japonica genomes. | |
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Abstract: The molecular evolution of the R2R3-MYB gene family is of great interest because it is one of the most important transcription factor gene families in the plant kingdom. Comparative analyses of a gene family may reveal important adaptive changes at the protein level and thereby provide insights that relate structure to function. We have performed a range of comparative and bioinformatics analyses on R2R3-MYB genes identified from the rice (Oryza sativa subsp. japonica and indica) and Arabidopsis genome sequences. The study provides an initial framework to investigate how different evolutionary lineages in a gene family evolve new functions. Our results reveal a remarkable excess of non-synonymous substitutions, an indication of adaptive selection on protein structure that occurred during the evolution of both helix1 and helix2 of rice R2R3-MYB DNA-binding domains. These flexible alpha-helix regions associated with high frequencies of excess non-synonymous substitutions may play critical roles in the characteristic packing of R2R3-MYB DNA-binding domains and thereby modify the protein-DNA interaction process resulting in the recognition of novel DNA-binding sites. Furthermore, a co-evolutionary pattern is found between the second alpha-helix of the R2 domain and the second alpha-helix of the R3 domain by examining all the possible alpha-helix pairings in both the R2 and R3 domains. This points to the functional importance of pairing interactions between related secondary structures. |
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| Journal | Plant Physiol. | |
| Country | USA | |
| Volume | 134(2) | |
| Pages | 575-85 | |
| Year | 2004 | |
| PubMed ID | 14966247 | |
| PubMed Central ID | 344534 | |
| DOI | 10.1104/pp.103.027201 | |
| URL | - | |
| Relation | ||
| Gene | 2R_MYB20 2R_MYB4 2R_MYB45 2R_MYB47 2R_MYB72 2R_MYB73 2R_MYB97 ALYL1 C CSA CSA2 DLN156 DLN231 DLN254 DLN31 FLP GAMYB GL1A GL1D MPS MYB1 MYB10 MYB102 MYB11 MYB12 MYB19 MYB2-76 MYB20 MYB21 MYB3R2 MYB4 MYB44 MYB4P MYB8 MYB9 PL SH11 _ _ _ _ _ _ _ _ _ _ | |
| INSD | - | |
| Strain | Wild Core Collection | - |
| Induced Mutation Lines(NIG Collection) | - | |
| Sterile Seed Strain | - | |
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Lethal Embryo Mutantion Strain |
- | |
|
Stages in Each Organ - Muant Lines (Gene) |
- | |
| Cultivated Varieties(NIG Collection) | - | |
| Stages in Each Organ | - | |
