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Reference Detail
| Reference | ||
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| Author | Masuda H., Ishimaru Y., Aung M.S., Kobayashi T., Kakei Y., Takahashi M., Higuchi K., Nakanishi H., Nishizawa N.K. | |
| Title | Iron biofortification in rice by the introduction of multiple genes involved in iron nutrition. | |
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Abstract: To address the problem of iron-deficiency anemia, one of the most prevalent human micronutrient deficiencies globally, iron-biofortified rice was produced using three transgenic approaches: by enhancing iron storage in grains via expression of the iron storage protein ferritin using endosperm-specific promoters, enhancing iron translocation through overproduction of the natural metal chelator nicotianamine, and enhancing iron flux into the endosperm by means of iron(II)-nicotianamine transporter OsYSL2 expression under the control of an endosperm-specific promoter and sucrose transporter promoter. Our results indicate that the iron concentration in greenhouse-grown T(2) polished seeds was sixfold higher and that in paddy field-grown T(3) polished seeds was 4.4-fold higher than that in non-transgenic seeds, with no defect in yield. Moreover, the transgenic seeds accumulated zinc up to 1.6-times in the field. Our results demonstrate that introduction of multiple iron homeostasis genes is more effective for iron biofortification than the single introduction of individual genes. |
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| Journal | Sci Rep | |
| Country | ||
| Volume | 2 | |
| Pages | 543 | |
| Year | 2012 | |
| PubMed ID | 22848789 | |
| PubMed Central ID | 3408131 | |
| DOI | - | |
| URL | - | |
| Relation | ||
| Gene | GLB1 GLUB1 SUT1 YSL2 | |
| INSD | - | |
| Strain | Wild Core Collection | - |
| Induced Mutation Lines(NIG Collection) | - | |
| Sterile Seed Strain | - | |
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Lethal Embryo Mutantion Strain |
- | |
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Stages in Each Organ - Muant Lines (Gene) |
- | |
| Cultivated Varieties(NIG Collection) | - | |
| Stages in Each Organ | - | |
