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Author Yang J., Zhao X., Cheng K., Du H., Ouyang Y., Chen J., Qiu S., Huang J., Jiang Y., Jiang L., Ding J., Wang J., Xu C., Li X., Zhang Q.
Title A killer-protector system regulates both hybrid sterility and segregation distortion in rice.
Hybrid sterility is a major form of postzygotic reproductive isolation that restricts gene flow between populations. Cultivated rice (Oryza sativa L.) consists of two subspecies, indica and japonica; inter-subspecific hybrids are usually sterile. We show that a killer-protector system at the S5 locus encoded by three tightly linked genes [Open Reading Frame 3 (ORF3) to ORF5] regulates fertility in indica-japonica hybrids. During female sporogenesis, the action of ORF5+ (killer) and ORF4+ (partner) causes endoplasmic reticulum (ER) stress. ORF3+ (protector) prevents ER stress and produces normal gametes, but ORF3- cannot prevent ER stress, resulting in premature programmed cell death and leads to embryo-sac abortion. Preferential transmission of ORF3+ gametes results in segregation distortion in the progeny. These results add to our understanding of differences between indica and japonica rice and may aid in rice genetic improvement.
Journal Science
Country China
Volume 337(6100)
Pages 1336-40
Year 2012
PubMed ID 22984070
PubMed Central ID -
DOI 10.1126/science.1223702
Gene BZIP50 CP1 S5 _ _
INSD JX138502 JX138503 JX138504 JX138505 JX138498 JX138499 JX138500 JX138501
Strain Wild Core Collection -
Sterile Seed Strain -
Lethal Embryo
Mutantion Strain
Stages in Each Organ
- Muant Lines (Gene)
Cultivated Varieties(NIG Collection) -
Stages in Each Organ -