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Author Lee S., Kim Y.S., Jeon U.S., Kim Y.K., Schjoerring J.K., An G.
Title Activation of Rice nicotianamine synthase 2 (OsNAS2) enhances iron availability for biofortification.
Abstract:
Because micronutrients in human diets ultimately come from plant sources, malnutrition of essential minerals is a significant public health concern. By increasing the expression of nicotianamine synthase (NAS), we fortified the level of bioavailable iron in rice seeds. Activation of iron deficiency-inducible OsNAS2 resulted in a rise in Fe content (3.0-fold) in mature seeds. Its ectopic expression also increased that content. Enhanced expression led to higher tolerance of Fe deficiency and better growth under elevated pH. Mice fed with OsNAS2-D1 seeds recovered more rapidly from anemia, indicating that bioavailable Fe contents were improved by this increase in OsNAS2 expression.
Journal Mol. Cells
Country USA
Volume 33(3)
Pages 269-75
Year 2012
PubMed ID 22228185
PubMed Central ID -
DOI -
URL -
Relation
Gene IRT1 IRT2 NAS2 YSL15 YSL2
INSD -
Strain Wild Core Collection -
Induced Mutation Lines(NIG Collection) -
Sterile Seed Strain -
Lethal Embryo
Mutantion Strain
-
Stages in Each Organ
- Muant Lines (Gene)
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Cultivated Varieties(NIG Collection) -
Stages in Each Organ -
/rice/oryzabase