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Reference Detail
| Reference | ||
|---|---|---|
| Author | Kaneda T,Taga Y,Takai R,Iwano M,Matsui H,Takayama S,Isogai A,Che FS | |
| Title | The transcription factor OsNAC4 is a key positive regulator of plant hypersensitive cell death. | |
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Abstract: The hypersensitive response (HR) is a common feature of plant immune responses and a type of programmed cell death. However, little is known about the induction mechanism of HR cell death. We report that overexpression of OsNAC4, which encodes a plant-specific transcription factor, leads to HR cell death accompanied by the loss of plasma membrane integrity, nuclear DNA fragmentation and typical morphological changes. In OsNAC4 knock-down lines, HR cell death is markedly decreased in response to avirulent bacterial strains. After induction by an avirulent pathogen recognition signal, OsNAC4 is translocated into the nucleus in a phosphorylation-dependent manner. A microarray analysis showed that the expression of 139 genes including OsHSP90 and IREN, encoding a Ca(2+)-dependent nuclease, were different between the OsNAC4 knock-down line and control line during HR cell death. During the induction of HR cell death, OsHSP90 is involved in the loss of plasma membrane integrity, whereas IREN causes nuclear DNA fragmentation. Overall, our results indicate that two important events occurring during HR cell death are regulated by independent pathways. |
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| Journal | EMBO J. | |
| Country | Japan | |
| Volume | 28 | |
| Pages | 926-36 | |
| Year | 2009 | |
| PubMed ID | 19229294 | |
| PubMed Central ID | - | |
| DOI | 10.1038/emboj.2009.39 | |
| URL | - | |
| Relation | ||
| Gene | HSP90 IREN NAC4 | |
| INSD | - | |
| Strain | Wild Core Collection | - |
| Induced Mutation Lines(NIG Collection) | - | |
| Sterile Seed Strain | - | |
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Lethal Embryo Mutantion Strain |
- | |
|
Stages in Each Organ - Muant Lines (Gene) |
- | |
| Cultivated Varieties(NIG Collection) | - | |
| Stages in Each Organ | - | |
