Update info.Tools - Reference - Detail
Reference Detail
| Reference | ||
|---|---|---|
| Author | Yang L,Kajiura H,Suzuki K,Hirose S,Fujiyama K,Takaiwa F | |
| Title | Generation of a transgenic rice seed-based edible vaccine against house dust mite allergy. | |
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Abstract: As an alternative approach to conventional allergen-specific immunotherapy, transgenic rice seed expressing a major house dust mite (HDM) allergen, Der p 1, was developed as an edible vaccine. The C-terminal KDEL-tagged Der p 1 allergen specifically accumulated in seed endosperm tissue under the control of the endosperm-specific GluB1 promoter. Der p 1 reached a maximum concentration of 58 microg/grain and was deposited in the endoplasmic reticulum (ER)-derived protein body I (PB-I). Plant-derived Der p 1 was posttranslationally modified with high-mannose-type glycan structures. Glycosylated Der p 1 displayed reduced IgE binding capacity in comparison with its unglycosylated counterpart in vitro. Our results indicate that transgenic Der p 1 rice seeds are a safe, potential oral delivery vaccine for the treatment of HDM allergy. |
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| Journal | Biochem. Biophys. Res. Commun. | |
| Country | Japan | |
| Volume | 365 | |
| Pages | 334-9 | |
| Year | 2008 | |
| PubMed ID | 17988639 | |
| PubMed Central ID | - | |
| DOI | 10.1016/j.bbrc.2007.10.186 | |
| URL | - | |
| Relation | ||
| Gene | GLUB1 | |
| INSD | - | |
| Strain | Wild Core Collection | - |
| Induced Mutation Lines(NIG Collection) | - | |
| Sterile Seed Strain | - | |
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Lethal Embryo Mutantion Strain |
- | |
|
Stages in Each Organ - Muant Lines (Gene) |
- | |
| Cultivated Varieties(NIG Collection) | - | |
| Stages in Each Organ | - | |
