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Author Li,Y., Li,W. and Jin,Y.X.
Title Computational identification of novel family members of microRNA genes in Arabidopsis thaliana and Oryza sativa
Abstract:
MicroRNAs (miRNAs) are a class of endogenous small RNAs that play important regulatory roles in both animals and plants. miRNA genes have been intensively studied in animals, but not in plants. In this study, we adopted a homology search approach to identify homologs of previously validated plant miRNAs in Arabidopsis thaliana and Oryza sativa. We identified 20 potential miRNA genes in Arabidopsis and 40 in O. sativa, providing a relatively complete enumeration of family members for these miRNAs in plants. In addition, a greater number of Arabidopsis miRNAs (MIR168, MIR159 and MIR172) were found to be conserved in rice. With the novel homologs, most of the miRNAs have closely related fellow miRNAs and the number of paralogs varies in the different miRNA families. Moreover, a probable functional segment highly conserved on the elongated stem of pre-miRNA fold-backs of MIR319 and MIR159 family was identified. These results support a model of variegated miRNA regulation in plants, in which miRNAs with different functional elements on their pre-miRNA fold-backs can differ in their function or regulation, and closely related miRNAs can be diverse in their specificity or competence to downregulate target genes. It appears that the sophisticated regulation of miRNAs can achieve complex biological effects through qualitative and quantitative modulation of gene expression profiles in plants.
Journal Acta Biochim. Biophys. Sin. (Shanghai)
Country China
Volume 37 (2)
Pages 75-87
Year 2005
PubMed ID 15685364
PubMed Central ID -
DOI -
URL -
Relation
Gene MIR156G MIR156K MIR156L MIR159A MIR160E MIR160F MIR162B MIR164C MIR164D MIR164E MIR164F MIR166B MIR166G MIR166H MIR166L MIR166M MIR166N MIR167F MIR167G MIR167I MIR167J MIR168A MIR169B MIR169C MIR169D MIR169F MIR169J MIR169K MIR169M MIR171B MIR171C MIR171D MIR171E MIR171F MIR171I MIR172A MIR172B MIR172C MIR172D MIR319A MIR319B miR159B miR159C miR159D miR159E miR159F
INSD AY551255 AY551256 AY551257 AY551258 AY551259 AY551210 AY551211 AY551212 AY551213 AY551214 AY551215 AY551216 AY551217 AY551218 AY551219 AY551220 AY551221 AY551222 AY551223 AY551224 AY551225 AY551226 AY551227 AY551228 AY551229 AY551230 AY551231 AY551232 AY551233 AY551234 AY551235 AY551236 AY551237 AY551238 AY551239 AY551240 AY551241 AY551242 AY551243 AY551244 AY551245 AY551246 AY551247 AY551248 AY551249 AY551250 AY551251 AY551252 AY551253 AY551254
Strain Wild Core Collection -
Induced Mutation Lines(NIG Collection) -
Sterile Seed Strain -
Lethal Embryo
Mutantion Strain
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Stages in Each Organ
- Muant Lines (Gene)
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Cultivated Varieties(NIG Collection) -
Stages in Each Organ -
/rice/oryzabase