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Reference Detail
| Reference | ||
|---|---|---|
| Author | Nagaki,K., Cheng,Z., Ouyang,S., Talbert,P.B., Kim,M., Jones,K.M., Henikoff,S., Buell,C.R. and Jiang,J. | |
| Title | Sequencing of a rice centromere uncovers active genes. | |
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Abstract: Centromeres are the last frontiers of complex eukaryotic genomes, consisting of highly repetitive sequences that resist mapping, cloning and sequencing. The centromere of rice Chromosome 8 (Cen8) has an unusually low abundance of highly repetitive satellite DNA, which allowed us to determine its sequence. A region of approximately 750 kb in Cen8 binds rice CENH3, the centromere-specific H3 histone. CENH3 binding is contained within a larger region that has abundant dimethylation of histone H3 at Lys9 (H3-Lys9), consistent with Cen8 being embedded in heterochromatin. Fourteen predicted and at least four active genes are interspersed in Cen8, along with CENH3 binding sites. The retrotransposons located in and outside of the CENH3 binding domain have similar ages and structural dynamics. These results suggest that Cen8 may represent an intermediate stage in the evolution of centromeres from genic regions, as in human neocentromeres, to fully mature centromeres that accumulate megabases of homogeneous satellite arrays. |
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| Journal | Nat Genet | |
| Country | USA | |
| Volume | 36(2) | |
| Pages | 138-145 | |
| Year | 2004 | |
| PubMed ID | 14716315 | |
| PubMed Central ID | - | |
| DOI | 10.1038/ng1289 | |
| URL | - | |
| Relation | ||
| Gene | CENH3 | |
| INSD | AY360384 AY360385 AY360386 AY360387 AY360388 AY360389 AY360390 AY360391 AY360393 AY360394 AY438639 | |
| Strain | Wild Core Collection | - |
| Induced Mutation Lines(NIG Collection) | - | |
| Sterile Seed Strain | - | |
|
Lethal Embryo Mutantion Strain |
- | |
|
Stages in Each Organ - Muant Lines (Gene) |
- | |
| Cultivated Varieties(NIG Collection) | - | |
| Stages in Each Organ | - | |
