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Reference Detail
| Reference | ||
|---|---|---|
| Author | Cobbe,N. and Heck,M.M.S. | |
| Title | The Evolution of SMC Proteins: Phylogenetic Analysis and Structural Implications | |
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Abstract: The SMC proteins are found in nearly all living organisms examined, where they play crucial roles in mitotic chromosome dynamics, regulation of gene expression, and DNA repair. We have explored the phylogenetic relationships of SMC proteins from prokaryotes and eukaryotes, as well as their relationship to similar ABC ATPases, using maximum-likelihood analyses. We have also investigated the coevolution of different domains of eukaryotic SMC proteins and attempted to account for the evolutionary patterns we have observed in terms of available structural data. Based on our analyses, we propose that each of the six eukaryotic SMC subfamilies originated through a series of ancient gene duplication events, with the condensins evolving more rapidly than the cohesins. In addition, we show that the SMC5 and SMC6 subfamily members have evolved comparatively rapidly and suggest that these proteins may perform redundant functions in higher eukaryotes. Finally, we propose a possible structure for the SMC5/SMC6 heterodimer based on patterns of coevolution. |
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| Journal | Mol. Biol. Evol. | |
| Country | UK | |
| Volume | 21(2) | |
| Pages | 332-347 | |
| Year | 2004 | |
| PubMed ID | 14660695 | |
| PubMed Central ID | - | |
| DOI | 10.1093/molbev/msh023 | |
| URL | - | |
| Relation | ||
| Gene | SMC6 _ _ _ _ _ | |
| INSD | AJ488495 AJ535209 AJ535210 AJ535211 AJ535212 AJ535213 | |
| Strain | Wild Core Collection | - |
| Induced Mutation Lines(NIG Collection) | - | |
| Sterile Seed Strain | - | |
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Lethal Embryo Mutantion Strain |
- | |
|
Stages in Each Organ - Muant Lines (Gene) |
- | |
| Cultivated Varieties(NIG Collection) | - | |
| Stages in Each Organ | - | |
